Decorin is an established natural oncosuppressive factor whose action is being studied in detail. Recently, decorin gene therapy formulations using adenoviral vectors have been shown in several animal models with very promising results. The present study describes the first exception to the established oncosuppression model using human osteosarcoma cells. MG-63 osteosarcoma cells were found to ...

Panax ginseng is a Chinese medicinal herb. Ginsenosides are the main bioactive components of P. ginseng, and ginsenoside Rg3 is the primary ginsenoside. Ginsenosides can potently kill various types of cancer cells. The present study was designed to evaluate the potential genotoxicity of ginsenoside Rg3 in human osteosarcoma cells and the protective effect of ginsenoside Rg3 with respect to N-me...

The human double minute (HDM)-2 E3 ubiquitin ligase plays a key role in p53 turnover and has been validated preclinically as a target in multiple myeloma (MM) and mantle cell lymphoma (MCL). HDM-2 inhibitors are entering clinical trials, and we therefore sought to understand potential mechanisms of resistance in lymphoid models. Wild-type p53 H929 MM and Granta-519 MCL cells resistant to MI-63 ...

Neochamaejasmin A is an individual compound isolated from Stellera chamaejasme and exerts antitumor effects on several types of human cancer cells. However, the effect neochamaejasmin osteosarcoma cells has not yet been investigated. The main aim was to detect in vitro MG-63 were treated with different concentrations (20, 40, 80 μg/ml). Cell viability detected by 3-(4,5-dimethylthiazol-2-yl)-2,...

Your Everyday, Average Academic The data described in this paper come from a unique cross section study collected by the author, using a postal questionnaire, of five Scottish Universities: Aberdeen, Dundee, Glasgow, Heriot-Watt and St. Andrews undertaken in 1995/6. It encompasses detailed information on the personal and working history of 900 academics. The paper aims to provide the reader wit...

Three binaries are now established sources of emission at very high energies (>10 eV). They are composed of a massive star and a compact object. The emission can be due to the interaction of the relativistic wind from a young ms pulsar with the stellar wind of the companion (Maraschi & Treves, 1981), by which rotation-power ends up as non-thermal flux. Variations at VHE energies are explained a...