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HYPOTHESIS Measurement of pelvic hemorrhage on computed tomographic (CT) scans can estimate the pelvic fracture component of total patient blood loss and predict the need for angiography. DESIGN Retrospective cohort study. SETTING Large level 1 trauma center. PATIENTS We examined data from 759 consecutive, nonreferral blunt trauma patients who sustained pelvic fracture. MAIN OUTCOME MEA...
A targeted therapy is recommended in case of ERBB2 alteration for breast and gastric carcinomas, but miscellaneous other tumor types are ERBB2-altered at low prevalence. Broadening the administration of HER2 inhibitors across tumor types and genomic alterations could benefit to patients with refractory metastatic tumors. Targeted next-generation-sequencing (tNGS) and comparative genomic hybridi...
OBJECTIVE To report on doctors' early choices of specialty at selected intervals after qualification, and eventual career destinations. DESIGN Questionnaire surveys. SETTING United Kingdom. PARTICIPANTS Total of 15 759 doctors who qualified in 1974, 1977, 1983, 1993, and 1996, and their career destinations 10 years after graduation. RESULTS 15 759 doctors were surveyed one and three yea...
BACKGROUND Trauma is one of leading cause of suffering to mankind. No study has yet been done to see the incidence, pattern of injury, outcome and declaration according to Qisas and Diyat in the city of Abbottabad. The objectives of the study were to determine the frequency of age and sex with type of lesion and causative weapon after trauma in a medico-legal clinic and to find the impact on th...
Prospective study of 164 young men from the start of employment in grain elevators showed that of those seen at the initial evaluation of respiratory state only 30% were available for a complete four year follow up. The drop out of subjects could represent a health related selection leading to the underestimation of respiratory effects of exposure to grain dust as assessed in the survivor group...
The Calcium Integrin Binding protein (CIB) has been identified as interacting specifically with the cytoplasmic tail of the integrin αIIb domain to induce receptor activation and integrin αIIbβ3 mediated cell adhesion to extracellular proteins. In K562 cells stably expressing mutated integrin αVβ3, or chimeric αVβ3 carrying αIIb cytoplasmic tail, we report that the interaction of CIB with β3 in...
INTRODUCTION The products of the serotonin receptor genes are important targets for conventional and atypical antipsychotics, and may be relevant for antipsychotic activity and associated adverse reactions. It has been shown that the high potency at 5-HT2 receptors may also be associated with the production of moderate extrapyramidal side effects (EPS). In addition, serotonin neurotransmitter s...
BACKGROUND Physical activity (PA) is well known to reduce the risk of cardiovascular disease. We hypothesized that regular PA, possibly acting through reductions in blood pressure and body mass index (BMI), would reduce the risk of incident atrial fibrillation (AF) in women. METHODS AND RESULTS We prospectively followed 34 759 women who reported their leisure-time PA levels for the occurrence...
Beta3 integrin adhesion molecules play important roles in wound repair and the regulation of vascular development and three beta3 integrin isoforms (beta3-A, -B, -C) have been described so far. Surface expression of beta3 integrins is dynamically regulated through internalization of beta3 integrins, however, the molecular mechanisms are understood incompletely. To evaluate the role of the cytop...
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