Annexin A1 is a multi functional molecule which is involved in inflammation, innate and adaptive immune systems, tumor progression and metastasis. We have previously showed the impaired tumor growth, metastasis, angiogenesis and wound healing in annexin A1 knockout mice. While tumor is a piece of heterogeneous mass including not only malignant tumor cells but also the stroma, the importance of ...

Heterogeneous ribonucleoprotein A1 (hnRNP A1) is crucial for regulating alternative splicing. Its integrated function within an organism has not, however, been identified. We generated hnRNP A1 knockout mice to study the role of hnRNP A1 in vivo The knockout mice, hnRNP A1-/-, showed embryonic lethality because of muscle developmental defects. The blood pressure and heart rate of the heterozygo...

In this paper, the existence of two A-type cyclins in the mouse is demonstrated. In the adult mouse, the expression of cyclin A1, which has greatest sequence identity with Xenopus cyclin A1, is restricted to germ cells. In contrast cyclin A2, which has greatest sequence identity with human cyclin A and Xenopus cyclin A2, is expressed in all tissues analysed. In order to explore the function of ...

BACKGROUND Both the A1- and A3-adenosine receptors (ARs) have been implicated in mediating the cardioprotective effects of adenosine. Paradoxically, overexpression of both A1-AR and A3-AR is associated with changes in the cardiac phenotype. To evaluate the temporal relationship between AR signaling and cardiac remodeling, we studied the effects of controlled overexpression of the A1-AR using a ...

The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) functions in the packaging of nascent RNA polymerase II transcripts and participates in a variety of nuclear and cytoplasmic processes that modulate gene expression. The RNA binding characteristics of hnRNP A1 suggest that it can modulate the expression of specific genes, but little is known about its possible targets in vivo. In this ar...

We have isolated and characterized the human homolog of the rat largest urea transporter of the UT-A family (hUT-A1). The 4.2-kb hUT-A1 cDNA encodes a 920-amino acid peptide, which is 89% identical to the rat UT-A1 protein. By Northern hybridization, hUT-A1 expression is detected in the human inner medulla as a approximately 4.4-kb mRNA transcript. By Western analysis, hUT-A1 is identified as a...

Let AkAk−1⋯A1 be the product of some nonnegative 2-by-2 matrices. In general, its elements are hard to evaluate. Under conditions, we show that ∀i,j∈{1,2}, (AkAk−1⋯A1)i,j∼cϱ(Ak)ϱ(Ak−1)⋯ϱ(A1) as k→∞, where ϱ(An) is spectral radius matrix An and c∈(0,∞) constant. Consequently, can estimated. As applications, consider maxima certain excursions (2,1) (1,2) random walks with asymptotically zero drif...

to the complex plane. We show that for fixed s 6= n/2, the function Zn(s; a1, . . . , an), as a function of (a1, . . . , an) ∈ (R) with fixed Qn i=1 ai, has a unique minimum at the point a1 = . . . = an. When Pn i=1 ci is fixed, the function (c1, . . . , cn) 7→ Zn (s; e c1 , . . . , en ) can be shown to be a convex function of any (n−1) of the variables {c1, . . . , cn}. These results are then ...

The Money Changing Problem is as follows: Let a1 < a2 < · · · < ak be fixed positive integers with gcd(a1, . . . , ak) = 1. Given some integer n, are there non-negative integers x1, . . . , xk such that ∑ i aixi = n? The Frobenius number g(a1, . . . , ak) is the largest integer n such that the above problem has no decomposition x1, . . . , xk. There exist algorithms that, for fixed k, compute t...

FcepsilonRI-activation-induced survival of mast cells is dependent on the expression and function of the prosurvival protein A1. The expression of A1 in lymphocytes and monocytes has previously been described to be transcriptionally regulated by NF-kappaB. Here we demonstrate that the expression of A1 in mast cells is not dependent on NF-kappaB but that NFAT plays a crucial role. FcepsilonRI-in...