نتایج جستجو برای: a3 locus
تعداد نتایج: 73843 فیلتر نتایج به سال:
BACKGROUND In the ASE/AIE-mediated genetic mechanism for age-related gene regulation, a recently identified age-related homeostasis mechanism, two genetic elements, ASE (age-related stability element) and AIE (age-related increase element as a stem-loop forming RNA), play critical roles in producing specific age-related expression patterns of genes. PRINCIPAL FINDING We successfully identifie...
Adoptive immunotherapy using TCR-engineered PBLs against melanocyte differentiation Ags mediates objective tumor regression but is associated with on-target toxicity. To avoid toxicity to normal tissues, we targeted cancer testis Ag (CTA) MAGE-A3, which is widely expressed in a range of epithelial malignancies but is not expressed in most normal tissues. To generate high-avidity TCRs against MA...
HE genetic structure of Streptomyces coelicolor A3 (2), the only strain among the actinomycetes for which a genetic map has been constructed, was studied in detail by HOPWOOD (1967) and SERMONTI (1 969). For genetic analysis, HOPWOOD and SERMONTI utilized the capacity of mutant strains of A3 (2) to undergo genetic recombination. To enlarge the possibilities of genetic analysis of the actinomyce...
مقدمه: msیک بیماری التهابی خود ایمن است که باعث تخریب میلین ها و اختلال در سیستم عصبی مرکزی می شود به این ترتیب انتقال پیام های عصبی با مشکل مواجهه میشود و این امر باعث ناتوانی های پیشرونده در بیماران مبتلا به ms میگردد. ms به عنوان یک بیماری مولتی فاکتوریال شناخته شده که از برهم کنش ژن ها و محیط ناشی می شود . ژن هایی که در این بیماری دخالت دارند شامل ژن های غیر وابسته به mhc و وابسته به mhc م...
BACKGROUND The management of patients with glioblastoma multiforme is difficult. Poor results have led to a search for novel therapeutic approaches. Gene therapy that could be both anti-invasive and antiangiogenic would be ideal. In this study, we constructed the recombinant adenoviral vector Ad-CALR/MAGE-A3 and evaluated its antitumor effects on glioblastoma in vitro and in vivo. METHODS In ...
background: current microscopic experimental methods cannot diagnose dna damages present in spermatozoa .therefore, some methods are needed to address the abnormality of the genetic material status on the sperm samples. as reported by many investigators aniline blue staining technique has been used for identifying sperm chromatin condensation. also, chromomycin a3 is used for evaluation of the ...
Incubation of (8R)- and (8S)-[1-14C]hepoxilin A3 [where hepoxilin A3 is 8-hydroxy-11,12-epoxyeicosa-(5Z,9E,14Z)-trienoic acid] and glutathione with homogenates of rat brain hippocampus resulted in a product that was identified as the (8R) and (8S) diastereomers of 11-glutathionyl hepoxilin A3 by reversed-phase high performance liquid chromatographic comparison with the authentic standard made b...
Background: Health locus of control is an important variable in diabetes. The aims of the present study were to investigate the role of health locus of control in predicting psychosocial adjustment to illness and compare psychosocial adjustment to illness and dimensions of health locus of control among male and female type 2 diabetic patients. Methods: One hundred and eighteen patients were ...
Background and Objectives: Diabetes is common among chronic diseases. Various factors such as personality and psychological traits have role in self-care and control in this disease Aim of This study is determination the relationship between self- care and locus of control in patients with type 2 diabetes. Method: This cross-sectional study carried out on 180 patients with diabetes mellitus typ...
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