We developed multiplex polymerase chain reaction (PCR) to detect aac(6 ')/aph(2 "), aph(3 ')-IIIa, and ant(4 ')-Ia, the genes encoding the most clinically relevant amino-glycoside modifying enzymes (AME), and simultaneously, the methicillin resistant gene, mecA, in Staphylococcus species. Clinical isolates of 45 S. aureus and 47 coagulase negative staphylococci (CNS) from tertiary university ho...

Wastewater discharged from clinical isolation and general wards at two hospitals in Singapore was examined to determine the emerging trends of antibiotic resistance (AR). We quantified the concentrations of 12 antibiotic compounds by analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS), antibiotic-resistant bacteria (ARB), the class 1 integrase gene (intI1), and 16 antibioti...

of Medicine, Gwangju, Korea i 42" 43" # Correspondence ( ): Seung-Ju Lee, M.D., Ph.D. 44" Department of Urology, St. Vincent's Hospital, The Catholic University of Korea, College of Medicine 45" 93-6 Ji-dong Paldal-gu, Suwon 442-723, South Korea 46" TEL: +82-31-249-7470 47" FAX: +82-31-253-0949 48" E-mail: [email protected] 49" AAC Accepts, published online ahead of print on 19 August 2013 ...

Mechanistic Assessment of DNA Ligase as an Antibacterial Target in Staphylococcus 1 aureus 2 3 Steven D. Podos, Jane A. Thanassi, and Michael J. Pucci* 4 Achillion Pharmaceuticals, New Haven, CT 06511 5 6 7 Running title: DNA Ligase as an antibacterial target 8 9 *Corresponding author 10 Mailing address: 11 Achillion Pharmaceuticals 12 300 George Street 13 New Haven, CT 06511 14 Phone: (203) 62...

Title: Improving the role and contribution of pharmacokinetic analyses in antimalarial drug 1 clinical trials 2 3 4 Running Title: Pharmacokinetics in antimalarial drug trials 5 6 Katherine Kay, Eva Maria Hodel and Ian M. Hastings 7 8 Authors affiliation: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, 9 UK 10 11 Corresponding author. Mailing address: Liverpool School ...

Acute acalculous cholecystitis (AAC) is an inflammation of the gallbladder in the absence of demonstrated stones. AAC is frequently associated with severe systemic inflammation. However, the exact etiology and pathogenesis of AAC still remain unclear. Acute infection with Epstein Barr virus (EBV) in childhood is usually aymptomatic, whereas it often presents as typical infectious mononucleosis ...

Approximately 1.3% of all people, or about 4 million Americans, cannot rely on their natural speech to meet their daily communication needs. Telepractice offers a potentially cost-effective service delivery mechanism to provide clinical AAC services at a distance to the benefit of underserved populations in the United States and worldwide. Tele-AAC is a unique cross-disciplinary clinical servic...

Historically, access in augmentative and alternative communication (AAC) has been conceptualized as the physical operation of AAC technologies; more recently, research and development in the cognitive and social sciences has helped to broaden the concept to include a range of human factors involved in the successful use of AAC technologies in social interactions. The goal of this article is to ...

A novel gene, aac(3)-Ic, encoding an AAC(3)-I aminoglycoside 3-N-acetyltransferase, was identified on a gene cassette inserted into a Pseudomonas aeruginosa integron that also carries a bla(VIM-2) and a cmlA7 gene cassette. The aac(3)-Ic gene product is 59 and 57% identical to AAC(3)-Ia and AAC(3)-Ib, respectively, and confers resistance to gentamicin and sisomicin.