Localized activation of the prodrug ifosfamide in or close to tumors by implanting encapsulated ifosfamide-activating cells is an efficacious strategy for tumor therapy. The aim of this study was to evaluate the feasibility of subsieve-size agarose capsules for enclosing the cells in this application. Compared with many conventional microcapsules, subsieve-size agarose capsules are about one-te...

In this paper we propose an alternative software model for modern computing environments. The new model features the decoupling of software execution from the computer hardware by encapsulating all software execution in an abstraction we call capsules. We treat capsules as first class objects that can be named, controlled, migrated, and replicated. We argue that by putting software execution in...

background: imatinib is known as the drug of choice for treatment of chronic myeloid leukemia (cml). for adults the recommended daily dosage of 400 mg requires simultaneous intake of up to four capsules or tablets each 100 mg. a new 400 mg film coated tablet developed due to the need to swallow multiple capsules or tablets per dose and that was a negative impact on treatment adherence. subjects...

OBJECTIVE The aims of this study were to quantify the extent of volatilization from 131I-NaI therapeutic capsules prepared in a centralized radiopharmacy and to quantify the amount of volatile 131I released from a dispensing vial containing a compounded 131I-NaI therapy capsule. METHODS Therapy capsules were prepared by injecting 131I oral solution into capsules containing anhydrous dibasic s...

Core exchangeable polymer-silica hybrid capsules with solvent-selective permeability were fabricated, in which the internal silica layer, formed from pre-included precursors, has the role of a framework to prevent irreversible deformation of the hollow capsules.

En ¿Qué es el tercer estado?, abate Sieyes hace depender la legitimidad política de los aportes en esfera productiva, creando un discurso o una retórica al servicio Revolución: porque pueblo llano realiza todos trabajos realmente útiles, y nobleza no más que carga para sociedad, estado nación completa, privilegiados –a ser dejen serlo– pueden formar parte ella. Sin embargo, mismo tiempo utilida...

Betaine is used to treat homocystinuria and is not available in Canada as a formulated drug. In order to facilitate the administration of this compound to patients, a capsule formulation and an evaluation of its stability were required. Capsule formulations of betaine were developed (160 mg and 625 mg of betaine per capsule). As betaine has no chromophore, an HPLC-ELSD analytical method was als...

Colloidal crystals are promising structures for photonic applications requiring dynamic control over optical properties. However, for ease of processing and reconfigurability, the crystals should be encapsulated to form 'ink' capsules rather than confined in a thin film. Here we demonstrate a class of encapsulated colloidal photonic structures whose optical properties can be controlled through ...

Alport syndrome is a hereditary, progressive disease characterized by progressive nephritis, sensorineural deafness, and ocular abnormalities, including anterior lenticonus. The ultrastructure of the lens capsule abnormalities in Alport syndrome is reported. Four anterior lens capsules from 31-year-old patient and 26-year-old patient with lenticonus who were affected by the Alport syndrome were...