BACKGROUND Plasma total cholesterol (TC) levels are highly genetically determined. Although ample evidence of genetic determination of separate lipoprotein cholesterol levels has been reported, using TC level directly as a phenotype in a relatively large broad-gene based association study has not been reported to date. METHODS AND RESULTS We genotyped 361 single nucleotide polymorphisms (SNPs...

BACKGROUND Gallstone disease is associated with p.D19H of ABCG8 as well as alterations of cholesterol and bile acid metabolism. However, molecular mechanisms have not been fully elucidated. It is important to understand the link between the sterol transporters ABCG5/8 and NPC1L1 and intestinal cholesterol absorption as well as de novo synthesis in gallstone patients stratified according to 19H ...

Abstract Background The expansion and metastasis of colorectal cancers are closely associated with the dynamic growth cancer stem cells (CSCs). This study aimed to explore possible effect LXR (a regulator glycolysis lipid hemostasis) in tumorgenicity human CD133 cells. Methods Human HT-29 + were enriched by MACS incubated agonist (T0901317) antagonist (SR9243) for 72 h. Cell survival was evalua...