Cervical cytological examination is the most widely applied screening method for cervical cancer and its precursors. Liquid-based cytology produces goodquality smears1 and enables the use of ancillary laboratory techniques to distinguish neoplastic from benign cells.1 Immunohistochemical and molecular markers have been tested to identify dysplastic cells in cervical smears. When testing for hum...

Background. There are limited data on high-risk human papillomavirus (hr-HPV) genotypes among HIV-positive women in Africa, and little is known about their relationship with cervical cytology in these populations. Methods. We conducted a cross-sectional study among 194 HIV-positive women (143 from Tanzania, and 51 from South Africa) to evaluate HPV genotypes among HIV-positive women with normal...

Human Papillomavirus (HPV) infections are known to cause cervical cancer worldwide, however, limited information is currently available on prevalence, types distribution and risk factors for HPV infection in the Arab countries. We conducted a cross-sectional observational study exclusively of women of Arabic origin residing in Qatar (n = 406) who were selected from the Women's Hospital at Hamad...

No longer is there argument that cervical screening can reduce deaths from cervical cancer. There is also agreement that the incidence of cervical intraepithelial neoplasia has risen appreciably in recent years' 2 and that without intervention deaths from cervical cancer in the 1990s will rise by 70% or more. The debate is now centring on what proportion of cases of cervical intraepithelial neo...

HIV-infected women have higher rates of persistence of human papillomavirus (HPV) infection, of abnormal cervical cytology results, and of cervical cancer than uninfected women. It is currently recommended that HIV-infected, sexually active women have a Papanicolaou (Pap) test performed at the time of initial diagnosis of HIV infection, followed by annual Pap testing if the previous test result...

BACKGROUND Pap cytology is known to be more specific but less sensitive than testing for human papillomavirus (HPV) for the detection of high-grade cervical intraepithelial neoplasia (CIN2+). We assessed whether p16/Ki-67 dual-stained cytology, a biomarker combination indicative of transforming HPV infections, can provide high sensitivity for CIN2+ in screening while maintaining high specificit...

OBJECTIVE To determine the clinical significance of the polymerase chain reaction (PCR)-reverse dot blot (RDB) human papillomavirus (HPV) genotyping assay in cervical cancer screening. METHODS A total of 10,442 women attending the Fujian Provincial Maternity and Children's Health Hospital were evaluated using the liquid-based cytology (thinprep cytologic test [TCT]) and the PCR-RDB HPV test. ...

We investigated the association between bacterial vaginosis (BV) and human papillomavirus (HPV) infection in Papanicolaou smears in a Brazilian population. Cross-sectional analysis was performed on 673 samples collected from women attending public health centers in Olinda (PE, Brazil) by conventional cytology methodology and molecular analysis, PCR tests (GP5+/6+ and MY09/11). Cytological abnor...

Because of the complexity of cervical cancer prevention guidelines, clinicians often fail to follow best-practice recommendations. Moreover, existing clinical decision support (CDS) systems generally recommend a cervical cytology every three years for all female patients, which is inappropriate for patients with abnormal findings that require surveillance at shorter intervals. To address this p...

A preliminary analysis was undertaken to ascertain whether a Leitz TAS (Texture Analyse System) video camera system, which is computer controlled, could be used to detect abnormal cells in cervical smears. Immunocytochemical together with haemalum nuclear staining was used for the epithelial membrane antigen. It was possible to detect abnormal cells in routinely prepared smears taken from patie...