Although cellular and molecular bases of proliferative diabetic retinopathy are only partially understood, it is evident that this complication of diabetes is characterized by the formation of new vessels inside the retina showing abnormal architecture and permeability. This process, if not controlled by selective laser photocoagulation, leads to irreversible retinal damages and loss of vision....

Abnormal α-synuclein (α-syn) accumulation in the CNS may underlie neuronal cell and synaptic dysfunction leading to motor and cognitive deficits in synucleinopathies including Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB). Multiple groups demonstrated α-syn accumulation in CNS accessory structures, including the eyes and olfactory terminals, as well as in peripheral organs of Par...

The retina has a high rate of oxygen consumption, and the retinal vessels are knoion to constrict with increased arterial oxygen tension and dilate ivhen arterial oxygen falls. In 10 subjects, measurement of retinal venous oxygen saturation by a photographic technique has shown an increase from 55 ± 8 per cent saturation breathing air to 82 ± 9 per cent breathing 100 per cent Os. This increase ...

PURPOSE To study the feasibility of performing retinal endovascular surgery with a microfabricated needle-based cannulation system at the level of the retinal microvasculature. METHODS A total of 40 retinal vein vessels, and 40 porcine eyes were used, and the eyecups were prepared under an operating microscope. Twenty retinal veins each were pierced with a microfabricated needle having an out...

Breakdown in the blood-retinal barrier occurs in retinal neovascularization in a number of diseases. To study the anatomic basis of this breakdown, we examined retinal neovascularization induced by injection of 250,000 homologous fibroblasts into the vitreous cavity of pigmented rabbits. Neovascularization is evident by electron microscopy in this model 3 days after fibroblast injection. Fluore...

The aim of the study was to investigate the correlation between the levels of C-reactive protein (CRP) and chitinase 3-like protein 1 (YKL-40) in blood samples with morpohometric parameters of retinal blood vessels in patients with diabetic retinopathy. Blood laboratory examination of 90 patients included the measurement of glycemia, HbA1C, total cholesterol, LDL-C, HDL-C, triglycerides and CRP...

A woman aged 42 was examined in the Casualty Department of the Royal Eye Hospital, London, at 8.30 p.m. on June 30, 1956. She complained of slight blurring of right vision associated with a little pain which had begun 7 hours before. This had never occurred previously. There was no history of physical strain or excitement, nor was there any relevant family or personal history concerning her ocu...