OBJECTIVE The objectives of the study were to determine the absolute bioavailability of fentanyl from fentanyl buccal soluble film, estimate the percentage of a fentanyl dose absorbed through the buccal mucosa, and compare the bioavailability of equivalent doses administered either as single or multiple dose units. DESIGN Open-label, randomized, four-period, Latin-square crossover pharmacokin...

The purpose of this study was to develop an in vivo screening method for rapid preclinical characterization of absorption and bioavailability of large numbers of compounds. This effort involved several steps. First, a pharmacokinetic characterization of a reference compound was conducted in the monkey. These data were used to verify theoretical calculations of a maximal portal dose-normalized a...

In this paper, we described and characterized a novel biplanar diode array, and demonstrated its applicability to dosimetric QA of the step-and-shoot IMRT. It is the first commercially available device of its kind specifically designed for measurements at varying gantry angles. The detector consists of a cylindrical PMMA phantom with two orthogonal detector boards. There are a total of 1069 p-t...

Dose-dense chemotherapy in the adjuvant and neoadjuvant setting has been intensively examined over the past few decades, and even seems to have become a standard regimen in certain subgroups of patients with increased risk of relapse. Nevertheless, there are conflicting data regarding the absolute benefit of this regimen, especially in the neoadjuvant setting. Pathological complete response (pC...

OBJECTIVE To examine the comparative efficacy and safety of antithrombotic treatments (apixaban, dabigatran, edoxaban, rivaroxaban and vitamin K antagonists (VKA) at a standard adjusted dose (target international normalised ratio 2.0-3.0), acetylsalicylic acid (ASA), ASA and clopidogrel) for non-valvular atrial fibrillation and among subpopulations. DESIGN Systematic review and network meta-a...

background: high level radiation areas have been recognized on various parts of the earth. mahallat hot spring region is one of these areas. study of exposure in these areas can be helpful in investigating the effects of ionizing radiation. internal and external exposure to the staff was studied. materials and methods: used materials and instruments include: rss-112 ionizing chamber for environ...

abstract introduction:  this study was performed to compare the effects of low-dose interferon beta-1(cinnovex,30 mcg) and high-dose interferon beta-1(rebif,44 mcg) on the reduction of the number and size of plaques in magnetic resonance imaging (mri) in patients with multiple sclerosis (ms). methods and materials: this historical cohort study, which was performed in 2014 in sanandaj (western p...

PURPOSE The contrast in dose distribution between proton radiotherapy (RT) and intensity-modulated RT (IMRT) is unclear, particularly in regard to critical structures such as the rectum and bladder. METHODS AND MATERIALS Between August and November 2006, the first 10 consecutive patients treated in our Phase II low-risk prostate proton protocol (University of Florida Proton Therapy Institute ...

PURPOSE In radical radiotherapy for cervical cancer, high-dose-rate (HDR) brachytherapy is commonly used after external beam radiation therapy (EBRT) to deliver a cumulative EQD2 of 80 to 90 Gy to the primary tumor. However, there is less certainty regarding brachytherapy dose contribution to the pelvic lymph nodes. This poses a challenge as to how high a preceding EBRT dose should be prescribe...