نتایج جستجو برای: accelerated ageing
تعداد نتایج: 84954 فیلتر نتایج به سال:
Does serum neurofilament light help predict accelerated cognitive ageing in unimpaired older adults?
Introduction Neurofilament light (NfL) is a blood biomarker of neurodegeneration. While serum NfL levels have been demonstrated to increase with normal ageing, the relationship between and age-related changes in cognitive functions less well understood. Methods The current study investigated whether cross-sectional measured by single molecule array technology (Simoa®) mediated effect age on cog...
BACKGROUND Type 2 diabetes (T2D) is associated with an increased risk of ischaemic heart disease (IHD). An accelerated process of vascular ageing induced by an increased oxidative stress exposure is suggested as potential pathway accounting for this association. However, no studies have explored the relationship between markers of vascular ageing, measures of oxidative stress and risk of IHD in...
Werner syndrome provides a convincing model for aspects of the normal ageing phenotype and may provide a suitable model for therapeutic interventions designed to combat the ageing process. Cultured primary fibroblast cells from Werner syndrome patients provide a powerful model system to study the link between replicative senescence in vitro and in vivo pathophysiology. Genome instability, toget...
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