OBJECTIVE To compare the effect of intensive versus standard glycemic control strategies on health-related quality of life (HRQL) in a substudy of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. RESEARCH DESIGN AND METHODS A randomly selected subsample of 2,053 ACCORD participants enrolled in the HRQL substudy was assessed at baseline and 12-, 36-, and 48-month visits. H...

The coiled-coil (CC) domain is a very important structural unit of proteins that plays critical roles in various biological functions. The major oligomeric state of CCs is a dimer, which can be either parallel or antiparallel. The orientation of each α-helix in a CC domain is critical for the molecular function of CC-containing proteins, but cannot be determined easily by sequence-based predict...

Funded through the UK Global Challenges Research Fund (GCRF) under NERC grant NE/P021050/1, and project ACCORD (as part of National Capability, Official Development Assistance award NE/R000123/1).

To investigate the relationships between respiratory control and the speech signal in the recitation of a story in English, Japanese, and Chinese, I compared and analysed the respiratory muscle movements utilising Strangage and simultaneously recorded speech signal. The subjects were English, Japanese and Chinese speakers. The results showed that (1) the Chinese showed no significant difference...

OBJECTIVE To determine the occurrence of extremely low HDL cholesterol (HDL-C) among participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Lipid Trial and to examine the relationship of this finding with treatment with fenofibrate and thiazolidinedione (TZD). RESEARCH DESIGN AND METHODS The ACCORD Lipid Trial was a randomized, double-blind, placebo-controlled study co...