Bone mass accrual is a major determinant of skeletal mass, governed by bone remodeling, which consists of bone resorption by osteoclasts and bone formation by osteoblasts. Bone mass accrual is inhibited by sympathetic signaling centrally regulated through activation of receptors for serotonin, leptin, and ACh. However, skeletal activity of the parasympathetic nervous system (PSNS) has not been ...

The principle omega-3 fatty acid in brain, docosahexaenoic acid (DHA), accumulates in the brain during perinatal cortical expansion and maturation. Animal studies have demonstrated that reductions in perinatal brain DHA accrual are associated with deficits in neuronal arborization, multiple indices of synaptic pathology including deficits in serotonin and mesocorticolimbic dopamine neurotransmi...

Late-onset (LO) toxicities are a serious concern in many phase I trials. Since most dose-limiting toxicities occur soon after therapy begins, most dose-finding methods use a binary indicator of toxicity occurring within a short initial time period. If an agent causes LO toxicities, however, an undesirably large number of patients may be treated at toxic doses before any toxicities are observed....

Graceful performance degradation during overload conditions is the primary objective of soft real-time systems. Utility accrual soft real-time scheduling algorithms allow speci cation of highly customized temporal system behavior during overload. Such algorithms are typically found in realtime supervisory systems where signi cant run-time uncertainty exists. This paper outlines an investigation...

Working memory (WM) is a buffer that temporarily maintains information, be it visual or auditory, in an active state, caching its contents for online rehearsal or manipulation. How the brain enables long-term semantic knowledge to affect the WM buffer is a theoretically significant issue awaiting further investigation. In the present study, we capitalise on the knowledge about famous individual...

Parallel Data processing has emerged to be one of the killer applications for Infrastructure-as-a-Service (IaaS) clouds. One of an IaaS cloud’s key feature is the provisioning of compute resources on demand. The computer resources available in the cloud are highly dynamic and possibly heterogeneous. Nephele is the first data processing framework to explicitly exploit the dynamic resource alloca...

Convenience, reliability, and effectiveness of automatic memory management have long been established in modern systems and programming languages such as Java. The timeliness requirements of real-time systems, however, impose specific demands on the operational parameters of the garbage collector. The memory requirements of real-time tasks must be accommodated with a predictable impact on the t...

Utility Accrual (UA) scheduling is a method of dynamic real-time scheduling that is designed to respond to overload conditions by producing a feasible schedule that heuristically maximizes a pre-defined metric of utility. Whereas utility accrual schedulers have traditionally focused on CPU overload, this dissertation explores memory overload conditions during which the aggregate memory demand e...

with Stage I and II disease there is excessive mortality per unit time as compared to the control population for at least 10 years after treatment. Thus, while the above definition is acceptable, the lag period required for the evaluation of potentially curative treatment is very long. In an attempt to determine the presence and degree of curative treatment in a shorter time, the relapse-free i...

Clinical trials are critical to improve AML treatment. It remains, however, unclear if clinical trial participation per se affects prognosis and to what extent the patients selected for trials differ from those of patients receiving intensive therapy off-trial.We conducted a population-based cohort study of newly diagnosed Danish AML patients treated with intensive chemotherapy between 2000-201...