Behavioral flexibility and goal-directed behavior heavily depend on fronto-striatal networks. Within these circuits, gamma-aminobutyric acid (GABA) glutamate play an important role in (motor) response inhibition, but it has remained largely unclear whether they are also relevant for cognitive inhibition. We hence investigated the functional of transmitters inhibition during flexibility. Healthy...

It has been difficult to establish a strong correlation between total brain T2-weighted lesion volume on MRI and clinical disability in multiple sclerosis, in part because of the lack of pathological specificity of T2-weighted MRI signal changes. Proton magnetic resonance spectroscopy studies have shown that measurements of the resonance intensity of N-acetylaspartate (which is localized exclus...

In light of current resistance to antimalarial drugs, there is a need to discover new classes of antimalarial agents with unique mechanisms of action. Identification of unique scaffolds from natural products with in vitro antiplasmodial activities may be the starting point for such new classes of antimalarial agents. We therefore conducted scaffold diversity and comparison analysis of natural p...

N-Acetylaspartic acid (NAA) occurs at relatively high concentrations exclusively in the mammalian and avian brain and undergoes rapid rise in level soon after birth (Tallan, 1957). The amount of NAA in brains of mentally abnormal human beings and of young human beings was measured. The route by which NAA is synthesized was shown to involve a direct acetylation of aspartic acid. The degradative ...

Preliminary Report on the Yale North India ExpeReports: dition: DR. H. DE TERRA .................. 497 Medals Presented at the Annual Dinner of the NaA History of the National Research Council, 1919tional Academy of Sciences....... ............514 1933. III. Diovision of Engineering and Industrial Scientific Apparatus and Laboratory Methods: Research: PROFESSOR DUGALD C. JACKSON ..................

The topic of the present study is an analytic verbal expression (exemplified in 1, below) that is commonly employed in Basse Mandinka, a regional variety of the Gambian Mandinka language. This construction is formed by the non-verbal locative predicator be ‘be’ (in the negative te), the verb naa ‘come’, the base of a “meaning” verb1 and the infinitive marker la ‘to’. This locution – in accordan...