This paper summarizes major achievements and challenges of software resource estimation over the last forty years. We address critical issues that enabled major achievements such as the development of good model forms, criteria for evaluating models, methods for integrating expert judgment and statistical data analysis, and processes for developing new models that cover new software development...

Being the most aggressive type of brain tumor, glioblastoma is estimated to be diagnosed in about 12,400 new cases in 2017. The diagnosis is dramatic to patients and relatives and leaves open many unanswered questions for them. One is the big question why there is no cure as in other tumors. This review illustrates the US and global research efforts that have been made over the past century. It...

In this paper, we introduce our work on SemEval-2012 task 5: Chinese Semantic Dependency Parsing. Our system is based on MSTParser and two effective methods are proposed: splitting sentence by punctuations and extracting last character of word as lemma. The experiments show that, with a combination of the two proposed methods, our system can improve LAS about one percent and finally get the sec...

We have recently announced a minor change in the editorial process of Dental Press Journal of Orthodontics (DPJO).1 All manuscripts submitted to the journal are now sent for initial analysis carried out by one of our associate editors. Should the associate editor, in conjunction with the editor-in-chief, decide that the article is of low level of priority, it will be immediately sent back to th...

Bioartificial kidneys (BAKs) combine a conventional hemofilter in series with a bioreactor unit containing renal epithelial cells. The epithelial cells derived from the renal tubule should provide transport, metabolic, endocrinologic and immunomodulatory functions. Currently, primary human renal proximal tubule cells are most relevant for clinical applications. However, the use of human primary...

Computational protein design (CPD), a yet evolving field, includes computer-aided engineering for partial or full de novo designs of proteins of interest. Designs are defined by a requested structure, function, or working environment. This chapter describes the birth and maturation of the field by presenting 101 CPD examples in a chronological order emphasizing achievements and pending challeng...

Combination antiretroviral therapy (ART) as we know it today has only been practiced in Africa in a significant segment of people living with HIV (PLH) in the past 6 years. We have put behind us the litany of reasons which were given as obstacles in the implementation of ART in Africa. Today the majority of the 5.2 million people on ART are from sub-Saharan Africa. Cohort comparisons between re...

1 Laboratory of Applied Entomology Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan, 2 Centre de Biologie et de Gestion des Populations (CBGP), UMR 1062, Institut National de la Recherche Agronomique (INRA), Campus International de Baillarguet, Montferrier-sur-Lez, France, 3 Laboratoire Dynamique de la Biodiversité, UMR CNRS 5172, Université Paul Sabatier...

Alcohol has been consumed in Australia since European settlement in 1788. In 1998, approximately 60% of Australians consumed an alcoholic beverage at least once per week. The effects of alcohol on the human body are dose dependent, where the harmful effects of alcohol are generally observed only when alcohol consumption exceeds moderate consumption levels of 30 to 40 g of alcohol per day. The d...