BACKGROUND Acral lentiginous melanoma (ALM) is an uncommon, cutaneous malignant tumour which may arise on the foot. Its relative rarity, atypical appearance and late presentation frequently serve as poor prognostic indicators. METHODS At a tertiary skin tumour centre, a retrospective review was undertaken of all patients diagnosed with the tumour at the level of ankle or below. RESULTS Over...

Acral melanoma has been reported to have distinctive clinical presentation and ethnic distribution compared to other histological types of malignant melanoma. Acral melanoma also exhibits distinctive focused gene amplifications, including cyclin D1 overexpression. We reviewed archived histological material of malignant melanoma in the Sarawak General Hospital from year 2004 to 2010. 43 tumours,...

Warfarin induced skin necrosis (WISN) is a rare but important side effect of warfarin. Early diagnosis may lessen the amount of permanent tissue damage and can prevent progression to full thickness skin necrosis. So, physicians should be aware of such a complication. Screening for protein C or S or anti-thrombin deficiencies, or presence of anti-phospholipid antibodies before beginning warfarin...

E ven by clinical and histologic findings alone it is reasonable to suspect that the pathogenesis of certain blistering skin diseases might involve abnormalities in adhesion structures. The best defined buUous diseases in this regard are pemphigus (of which there are two basic types: vulgaris and foliaceus) and bullous pemphigoid (BP) (1-3). Histology shows that the blisters in pemphigus result...

Introduction: Impetigo is a common infection of the superficial layers epidermis that highly contagious and usually originated by gram-positive bacteria, this disease manifests with presence erythematous plaques yellow crust, which may become itchy or painful. Diagnosis based on signs symptoms alone. Treatment involves topical oral antibiotics symptomatic care. Objective: to detail current info...

Background Postoperative pyoderma gangrenosum (PPG) is a rare inflammatory skin disease of unknown etiology characterized by blistering and ulcerative lesions in postoperative wounds. Untreated (PG) potentially life-threatening; therefore, immediate appropriate treatment essential. Although PPG surgical site infection (SSI) present similar clinical findings, they should be differentiated becaus...

A 63-yr-old housewife was referred in August 2001 with a 10-yr history of gradually worsening breathlessness on exertion, cough and repeated respiratory tract infections. She had never smoked. She had been diagnosed with follicular B-cell non-Hodgkin9s lymphoma 10 yrs previously, which was treated with chemotherapy, including chlorambucil, vincristine and prednisolone, and subsequent radiothera...

A case is presented of a female Caucasian patient with chronic peripheral blood eosinophilia and unusual skin manifestations. Within a couple of years, the patient developed multiple hyperkeratotic and hyperpigmented papules and plaques all over the body, palmoplantar keratoderma, pachydermia of acral parts of the body, and generalized pruritus. Generalized lymphadenopathy appeared. Other relev...