Dario D. Salvucci ([email protected]), Michael D. Byrne ([email protected]), Christian Lebiere ([email protected]), Niels A. Taatgen ([email protected]) J. Gregory Trafton ([email protected]) 1 College of Computing & Informatics, Drexel University, 3141 Chestnut St., Philadelphia, PA 19104, USA 2 Department of Psychology, Rice University, 6100 Main St., Houston, TX 77005, USA 3 Department of Psyc...

The crystal structure of a HECT E3 enzyme has been captured as it transfers ubiquitin to a target protein, revealing the dramatic changes in shape that enable it to modify particular residues in its targets.

The integrin reconstruction act " I n biology, you really know what you're talking about when you can reconstruct a system synthetically, " says Mark Ginsberg from UC San Diego. That hasn't been possible in the case of integrin activation—the process by which integrin adhesion receptors gain an increased affi nity for their extracellular matrix ligands. The activation mechanism has been highly ...

A novel approach for the study of games with strategic uncertainty is proposed. Games are defined such that players’ strategy spaces do nor only contain pure and mixed strategies but also contain “ambiguous act strategies”, in the sense that players can base their choices on subjective randomization devices. The notions of “independent strategies” as well as “common priors” are relaxed in such ...

We present the NBA framework, which extends the architecture of the Click modular router to exploit modern hardware, adapts to different hardware configurations, and reaches close to their maximum performance without manual optimization. NBA takes advantages of existing performance-excavating solutions such as batch processing, NUMA-aware memory management, and receiveside scaling with multi-qu...

This paper presents a machine learning-based approach to the incremental understanding of dialogue utterances, with a focus on the recognition of their communicative functions. A token-based approach combining the use of local classifiers, which exploit local utterance features, and global classifiers which use the outputs of local classifiers applied to previous and subsequent tokens, is shown...

This paper deals with automatic dialogue act (DA) recognition. Dialogue acts are sentence-level units that represent states of a dialogue, such as questions, statements, hesitations, etc. The knowledge of dialogue act realizations in a discourse or dialogue is part of the speech understanding and dialogue analysis process. It is of great importance for many applications: dialogue systems, speec...

Robotic hands built for manipulation are often anthropomorphic but not anatomically accurate. We are constructing an anatomically-correct testbed (ACT) of the human hand to understand its mechanisms, function, and control. We have previously demonstrated that an accurate model of the extensor mechanism in the ACT Hand is crucial in realizing the human-like finger movements. Here, we present des...