The properties of mouse macrophage procoagulant induced by endotoxin in vitro were studied by the acceleration of clotting and by chromogenic assays using as substrates human plasma and bovine components, which are not activated by mouse tissue factor. Maximal macrophage procoagulant activity occurred when activated cells were lysed in culture supernatant fluids, suggesting the interaction of c...

PURPOSE There are an increasing number of anecdotal reports and trials of recombinant activated factor VII (rFVIIa) for bleeding during surgery. The reports of rFVIIa during cardiac surgery are limited. We report our experience using rFVIIa, in the operating room; to treat bleeding that prevented chest closure, despite appropriate conventional treatment, following complex cardiac surgery. MET...

s published in national and international journalsDiaconescu, R., Stancu, C. C., Coteanu M.F. 2013, „ Hemostatic therapy for acuteintracerebral hemorrhage”, Romanian Journal of Neurology/ Revista Romana deNeurologie, vol. XII, no. 1 Suppl, pp. 49-50.Diaconescu, R., Stancu, C. C., Coteanu M.F. 2013, „ A comparative effectivenessstudy of recombinant activated factor VII in off...

BACKGROUND AND PURPOSE Life-threatening intracranial hemorrhage, predominantly intracerebral hemorrhage (ICH), is the most serious complication of oral anticoagulant therapy (OAT), with mortality in excess of 50%. Early intervention focuses on rapid correction of coagulopathy in order to prevent continued bleeding. SUMMARY OF REVIEW This article reviews the epidemiology of OAT-associated ICH ...

OBJECTIVE To describe the use of thromboelastography (TEG) to direct hemostatic resuscitation in a child with traumatic injury requiring massive transfusion. DESIGN Case report. SETTING Level 1 pediatric trauma center in an academic tertiary care facility. PATIENT A 5-year-old boy with grade IV liver injury and right common hepatic artery laceration. INTERVENTION TEG-directed resuscitat...