The OpeNER Linked Dataset (OLD) contains 19.140 entries about accommodations in Tuscany (Italy). For each accommodation, it describes the type, e.g. hotel, bed and breakfast, hostel, camping etc., and other useful information, such as a short description, the Web address, its location and the features it provides. OLD is the linked data version of the open dataset provided by Fondazione Sistema...

The ideal agent for prevention and treatment of uterine abnormal contractility has not been found. The polyphenol resveratrol possesses a wide spectrum of pharmacologic properties, but its influence on the contractility of human myometrium is not defined. The present study evaluated the effect of resveratrol on the oxytocin-induced contractions of human term pregnant myometrium in vitro and the...

stand establishment in crusting soil is one of the main concerns in the production of crops with delicate seedlings such as cotton, onions and rape seed. crust breaking, maintaining soil moisture and adding chemical and organic amendments to soil are different methods to weaken soil strength and allow the shoots to emerge. these methods are not always successful because they depend on factors s...

AIM To investigate whether ATP-sensitive potassium (K(ATP)) channels modulate the tocolytic effect of β2-adrenergic receptor (β2-AR) agonists (ritodrine and salmeterol) in early-pregnant (day 6) and late-pregnant (day 22) rat uterus in vitro, in order to examine the relation between the K(ATP) channel sulphonylurea-binding regulatory subunit (SUR) expression and pharmacological reactivity of β2...

KATP blockers derived from cyanoguanidine KATP opener (P1075) chemistry were characterized in isolated rabbit mesenteric artery and evaluated functionally by their ability to antagonize maximal relaxation induced by pinacidil (1 microM) of norepinephrine (5 microM) contraction. PNU-89692, PNU-97025E and PNU-99963 were identified as KATP blockers with IC50 values of 860, 83 and 18 nM, respective...

Objectives: The mechanism by which the mitochondrial K channel openers confer protection against ischemia / reperfusion injury is ATP debated. Evidence suggests that rather than solely being an end effector, opening of these channels may act by a trigger mechanism. We examined the effects of the mitochondrial K channel opener, diazoxide on parameters of mitochondrial function with specific refe...

Different furrow openers are required to be evaluated for their suitability to manage rice straw for direct planting of wheat in paddy fields. This study was carried out to assess the straw-cutting ability and draft requirements of four different disc-type furrow openers (notched, toothed, smooth-edge single disc, and double disc) in no-till paddy fields. The openers were attached to an in-fiel...

Our recent study has revealed that 12,14-dichlorodehydroabietic acid (diCl-DHAA), which is synthetically derived from a natural product, abietic acid, is a potent opener of large conductance Ca(2+)-activated K(+) (BK) channel. Here, we examined, by using a channel expression system in human embryonic kidney 293 cells, the mechanisms underlying the BK channel opening action of diCl-DHAA and whic...

BACKGROUND This study used monophasic action potential (MAP) to examine the effect of nicorandil, a K+ channel opener, on repolarization abnormalities induced by epinephrine in the LQT1 form of congenital long-QT syndrome in which the KvLQT1 mutation underlies the defect in the channel responsible for the slowly activating component of the delayed rectifier potassium current. METHODS AND RESU...

As activated microglia (MG) is an early sign that often precedes and triggers neuronal death, inhibition of microglial activation and reduction of subsequent neurotoxicity may offer therapeutic benefit. The present study demonstrates that rat primary cultured MG expressed Kir6.1 and SUR2 subunits of K(ATP) channel, which was identical to that expressed in BV-2 microglial cell line. The classic ...