The bone marrow of a patient with acute undifferentiated leukemia developed unique colonies after a 14-day culture in erythropoietin (EPO)-containing methylcellulose. The colonies consisted of 20 to 200 nonhemoglobinized large blast cells. Cytogenetic analysis of single colonies revealed hypotetraploid karyotypes with several marker chromosomes that were identical to those found in directly sam...

The morphologic dysplasia manifested in any lineage(s) frequently does not correlate with the specific cytopenia(s) in individual MDS cases. For this reason, WHO revision for adult MDS classification in 2016 removes terms such as “refractory anemia” and “refractory cytopenia” and replaces them with “myelodysplastic syndrome” followed by the appropriate modifiers: single vs multilineage dysplasi...

Ferrokinetics data on patients with blood disorders of diverse etiology were presented and the clinical implication of this test was discussed. Ferrokinetics data on normal adults as well as on the aged were also presented. Ferrokinetic patterns of ineffective erythropoiesis were obtained on patients with pernicious anemia, erythroleukemia, myelofibrosis, paroxysmal nocturnal hemoglobinuria and...