Severe immunosuppression is an established risk factor for non-Hodgkin lymphoma (NHL), but an association with subclinical immune dysfunction is unclear. We conducted a case-control study nested in the Physicians' Health Study and the Nurses' Health Study cohorts to determine whether patterns of antibody response to Epstein-Barr virus (EBV) were associated with NHL risk. We measured antibody ti...

In 1950, patients with Hodgkin lymphoma had a median survival time of 4 years and a 5-year relative survival rate of 29% (1). Since the introduction of radiation therapy and chemotherapy for Hodgkin lymphoma in the 1960s and 1970s, the 5-year relative survival rate is more than 85% (2), and these patients can now expect a long lymphoma-free life. However, the price for this phenomenal success h...

background : acute lymphocytic leukemia is one of the common cancers of childhood and currently, 80 percent of these children survive more than 5 years by getting the right treatment. since long-term treatment is painful and invasive, preventing the side effects and their influence on quality of life is an important issue which introduces consideration for self-care. consequently, the present s...

BACKGROUND Hepatitis B Virus (HBV) is responsible for chronic, acute, and fulminant hepatitis, which are prevalent worldwide. Chronic HBV may lead to cirrhosis and hepatocellular carcinoma. Several epidemiological studies have indicated that hepatitis B virus is involved in B-cell Hodgkin and Non-Hodgkin Lymphoma (NHL). OBJECTIVES The aim of this study was to evaluate the association between ...

The B-cell lymphoma-2 (BCL-2) family of proteins are essential components in the intrinsic apoptosis pathway. While a primary mechanism for removal damaged or unwanted cells, dysregulation this pathway is observed many human cancers. Specifically, BCL-2 overexpression has been associated with pro-survival multiple hematological and solid tumor malignancies. In clinic, inhibitors have demonstrat...

OBJECTIVE(S) Non- Hodgkin lymphoma (NHL) and acute lymphoblastic leukemia (ALL) are two main hematological malignances which have been driven from lymphoid tissue. Genetic polymorphisms in tumor necrosis factor-α (TNF-α) -308 and lymphotoxin-α (LT-α) +252 may affect their transcription and expression which leads to their high plasma level. The frequency of the TNF-α (-308) and LT-α (+ 252) poly...

chromatin-associated DNA-directed DNA polymerase activity, and the soluble RNase-sensitive endogenous DNA polymerase activity were examined in two fibroblast cell lines (WI-38 and WI-38VA13), in thirteen lymphoid cell lines originated from normal persons or from acute lymphocytic leukemia, acute myelocytic leukemia, Burkitt lymphoma, or multiple myeloma patients, and also in cells obtained dire...

Few large population-based studies have investigated the effects of biologic agents on risks lymphoproliferative disorders (LPDs) and skin cancers in patients with psoriasis inflammatory bowel disease (IBD). The objective this study are to assess risk LPDs South Korean IBD determine those risks. Health Insurance Review Assessment Service database was reviewed, newly diagnosed or between 2008 20...