نتایج جستجو برای: acute promyelocytic leukemia

تعداد نتایج: 688410  

2015
Eduardo A. Rodriguez Marvin A. Lopez Kartik Valluri Danlu Wang Andrew Fischer Tatiana Perdomo

BACKGROUND The gastrointestinal tract is a rare site for extramedullary involvement in acute promyelocytic leukemia (APL). CASE REPORT A 43-year-old female with no past medical history presented complaining of mild abdominal pain, fever, and chills for the past day. On examination, she was tachycardic and febrile, with mild tenderness of her right lower quadrant and without signs of peritonea...

Journal: :Science signaling 2015
Domenico Fasci Veronica Anania Jennie Lill Guy Salvesen

Arsenic trioxide chemotherapy cures acute promyelocytic leukemia by inducing the ubiquitylation of an oncogenic fusion protein containing promyelocytic leukemia protein (PML) subsequent to modification of PML by SUMO1 and SUMO2. We proposed that the SUMO switch at Lys(65) of PML enhanced subsequent SUMO2 conjugation to Lys(160) and consequent RNF4-dependent ubiquitylation of PML. Ferhi et al no...

Journal: :IOSR Journal of Pharmacy (IOSRPHR) 2012

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