The incidence of acute kidney injury (AKI), previously called acute kidney failure (ARF), in emergency hospitals worldwide is highly independent of its different underlying causes. The use of certain antibiotics, like gentamicin, which determines the rapid loss of kidney ability to remove waste and stabilize the balance of fluids and electrolytes, finally causing AKI in child, is well known, an...

INTRODUCTION Acute tubular necrosis (ATN) is a challenging problem that still requires to be studied in animal models. Our aim was to prepare an established experimental model of inducing reversible ATN in rats by determining the optimum duration of ischemia induction to the kidney. MATERIALS AND METHODS Twenty-four hour after nephrectomy of the right kidney and clamping the pedicle of the le...

BACKGROUND/AIM Fas ligand (FasL) and tumor necrosis factor (TNF)-α are major pro-apoptotic molecules and also induce inflammation through cytokine and chemokine production. Although precise intracellular mechanisms of action have been reported for each molecule, the differential impact of these molecules on kidney injury in vivo still requires clarification. METHODS We explored the differenti...

Around 60 to 70 percent of the people from India reside in rural areas and usually opt for herbal medicine illness local traditional practitioners before seeking allopathic advice. Kidneys play a central role excretion metabolites these substances or themselves. Renal injury happens form acute tubular necrosis, interstitial nephritis, rhabdomyolysis, nephrolithiasis, urothelial cancers rarely r...

A method of studying the topographical distribution and cytological characteristics of the glandular cells of the human adenohypophysis was described in a previous report.' A cell classification based on probable functional significance was introduced in an attempt to achieve a greater degree of correlation between morphological and clinical observations. Application of this method to a group o...

Adrenocorticotropic hormone (ACTH) has a renoprotective effect in chronic kidney disease; however, its effect on acute kidney injury (AKI) remains unknown. In a rat model of tumor necrosis factor (TNF)-induced AKI, we found that ACTH gel prevented kidney injury, corrected acute renal dysfunction, and improved survival. Morphologically, ACTH gel ameliorated TNF-induced acute tubular necrosis, as...

RATIONALE Povidone-iodine is a broad-spectrum antiseptic applied topically to treat wounds and prevent their infection. There have been several case reports of acute kidney injury (AKI) in burn patients after povidone-iodine irrigation and in patients receiving the substance as a sclerotherapy agent for management of lymphocele after renal transplantation. However, biopsy-confirmed AKI after in...

Dr. T. Rudra, Cardiff Royal Infirmary (West Wing), Newport Road, Cardiff CF2 1SZ (UK) Dear Sir, We report survival of a patient following a drug reaction to co-trimoxazole. The patient suffered acute tubular necrosis and bone marrow, liver and dermal involvement, including scrotal infarction. Although multisystem involvement [1] and interstitial nephritis are known, there has been only one prev...

Atrial natriuretic peptides (ANPs) are a family of peptide hormones, e.g., ANP, long-acting natriuretic peptide, vessel dilator, and kaliuretic peptide synthesized by the ANP gene. Brain natriuretic peptide (BNP) and C-type natriuretic peptide are also members of this family but are synthesized by separate genes. Within the kidney, the ANP prohormone's posttranslational processing is different ...