coronary  atherosclerotic  disease  is  one  of  the  most  endangering  health  disorder worldwide. this study was designed to investigate the correlation between hla-drβ1 alleles and circulating th1/th2 type cytokines in coronary atherosclerosis. by elisa, th1/th2 type cytokines were determined in serum samples of 31 subjects with unstable angina, 27 subjects with chronic stable angina and 24...

HIGHLIGHTS • Adenosine induces a reduction in blood pressure, heart rate and renal flow. Caffeine (30 mg/kg) blocked all the cardiovascular changes induced by adenosine. The effect of caffeine lasts for 4 hours.

introduction: considering high prevalence of epileptic disease and considering that 40 percent of epileptic patients are resistant to drug therapy, it needs more researches to find new therapeutic ways. lfs is among the new methods for epilepsy treatments. one possible mechanism involved in the anticonvulsant effect of lfs is increased adenosine. therefore, in this study the role of adenosine p...

epilepsy is among the most common disorders of the central nervous system and there is not an absolute method for its treatment. it has been shown that each seizure has a depressing effect on the following seizure. thus, finding the mechanisms responsible in this phenomenon can improve our knowledge toward new ways for epilepsy treatment. in this study, the role of adenosine a1 receptors in pos...

background and objective: brucellosis is a main transmittable zoonotic disease, which is endemic, and a common health burden in iran. adenosine deaminase (ada) is an essential enzyme which is involved in purine metabolism and its role in immune system is very important. the aim of this study was to determine serum changes of ada and c-reactive protein (crp) levels in patients with brucellosis. ...

Background: We report the analgesic efficacy of lumbar epidural adenosine injection in reducing the chronic neuropathic pain in a patient with primitive neuroectodermal tumor. Report of the Case: In this case report a 13-year-old male with primary neuroectodermal tumor (PNET) was administered in epidural space with adenosine to reduce his pain. The patient received 10ml of 0.25% ropivacaine ...

A 52-year-old man presented to the outpatient clinic with dyspnea on exertion and atypical angina. Cardiovascular risk factors were a history of smoking (25 pack years) and hypertension, and the pretest risk probability for coronary artery disease was 49%. The coronary artery calcium score (CACS) was 0; however, because of symptoms coronary CT angiography (CTA) was performed which showed a seve...

in this study the effect of adenosine and caffeine on spontaneous activity of paragigantocellularis (pgi) neurons was investigated. the spontaneous activity of pgi neurons was significantly decreased by microinjection of adenosine (10 nm, 0.5 µl) into pgi nucleus of both control and morphine-dependent rats. the decrease in firing rate of pgi neurons of morphine-dependent rats was greater than t...