Direct dimolar pentanoylation of octyl ?-D-glucopyranoside (OBG) in pyridine-chloroform solvent system furnished the corresponding 3,6-di-O-pentanoate improved yield. The pentanoate was further converted into three 2,4-di-O-acyl esters to get novel glucopyranosides. To explore medicinal probability OBG-based all synthesized compounds were subjected for silico PASS (prediction activity spectra s...

In this study, methyl α-D-glucopyranoside and its modified derivatives were optimized by employing density functional theory (DFT) with B3LYP/3-21G level to explore their structural thermodynamic properties. Electronic energies, enthalpies, Gibbs free dipole moments, Highest occupied molecular orbital (HOMO)-lowest unoccupied (LUMO) gaps, the of states (DOS) electrostatic potential (MEP) these ...

It was depicted that the coumarin sulfonate derivatives were synthesized and reported tyrosinase pancreatic lipase inhibitory effects in silico application. In addition, compounds designed by introducing a sulfonyl group bearing functional groups such as nitro, methoxy, chlorine, methyl, naphthyl thiophenyl motifs. The characterizations of carried out utilizing 1H NMR, 13C HRMS analyses. Also, ...

As we know ACAT enzyme is responsible for the catalysis of cholesterol into cholesteryl esters leading to Hyperlipidemia which directly linked with cardiac problems. Throughout world problems are causing increased mortality. This study aims synthesize and screen pharmacologically active compound from best five compounds docked having good binding affinity found in our earlier research against e...

Plant Based Natural Products (PBNPs) are the primary source of natural antioxidants capable neutralizing or eliminating harmful Reactive Oxygen Species (ROS). Oxidative stress contributes not only to pathogenesis type 2 diabetes (T2DM) but also diabetic related vascular complications by lipid peroxidation. Oxidation induced DNA and protein damage leads development like coronary heart disease, C...