Psychiatric adverse effects during systemic corticosteroid therapy are common. Two large meta-analyses found that severe reactions occurred in nearly 6% of patients, and mild to moderate reactions occurred in about 28%. Although disturbances of mood, cognition, sleep, and behavior as well as frank delirium or even psychosis are possible, the most common adverse effects of short-term corticoster...

High doses of synthetic antioxidative vitamins: A, E, C and β-carotene are often used on long-term basis in numerous preventive and therapeutic medical applications. Instead of expected health effects, the use of those vitamins may however lead to cases of hypervitaminosis and even to intoxication. The article points out main principles of safety which are to be observed during supplementation ...

In the article entitled "Laboratory profiles of treatmentseeking subjects with concurrent dependence on cannabis and other substances: A comparative study", authors have focused on the systemic adverse effects of cannabis consumption through the evaluation of routine hematological parameters. Cannabis is extensively studied for its effects on the central nervous system, while its long term effe...

Attention to known contraindications and intercurrent illness can avoid life-threatening acidosis.

Optimal protection against preventable diseases for adolescents can be provided through routine vaccination. Vaccinations recommended by the Advisory Committee on Immunization Practices of the Centers of Disease Control and Prevention can reduce morbidity and mortality associated with influenza, meningococcal, human papillomavirus, tetanus, diphtheria, and pertussis infections. Most reported ad...

This article brings an overview of mycotoxin co-occurrence in foods in Croatia and neighbouring countries and experimental data from mycotoxin interaction studies involving Fusarium toxins, ochratoxin A (OTA), and aflatoxin B(1) (AFB(1)). Only a few studies of combined mycotoxin toxicity have employed a mathematical/ statistical design, while others have used common statistics in order to compa...

The consumption of fructose, primarily from high-fructose corn syrup (HFCS), has increased considerably in the United States during the past several decades. Intake of HFCS may now exceed that of the other major caloric sweetener, sucrose. Some nutritionists believe fructose is a safer form of sugar than sucrose, particularly for people with diabetes mellitus, because it does not adversely affe...

Pharmacoepidemiology has been defined as “the study of the distribution and determinants of drugrelated events in populations and the application of this study to efficacious drug treatment” [26]. Similar definitions have been given by several authors [37, 53]. The term “drug” in the definition is generally understood to include biologics, such as vaccines, and the populations are understood to...