Pulmonary drug delivery can have several advantages over other administration routes, in particular when using dry powder formulations. Such inhalation formulations generally include natural and bio-inspired excipients, which, among purposes, are used to improve dosing reproducibility aerosolization performance. Amino acids enhance dispersibility provide protection against moisture uptake. Suga...

A renewable source of carbon black is introduced by the processing lignin from agro-forestry residues. Lignin side streams are converted into spherical particles direct aerosolization followed carbonization. The obtained submicron combined with cellulose nanofibers, which act as a binder and rheology modifier, resulting in new type colloidal bioink. bioinks tested handwriting ink writing. After...

A direct method was developed to determine the viability of a freshly generated mixed bacterial aerosol. A mixed suspension of (32)P-labeled Staphylococcus aureus and (35)S-labeled Proteus mirabilis was nebulized, and the aerosol was collected and separated according to particle size with an Andersen sampler. Quantitative and qualitative bacteriological and radioisotopic techniques were used to...

Repeated transmission of animal influenza viruses to humans has prompted investigation of the viral, host, and environmental factors responsible for transmission via aerosols or respiratory droplets. How do we determine-out of thousands of influenza virus isolates collected in animal surveillance studies each year-which viruses have the potential to become 'airborne', and hence pose a pandemic ...

To effectively predict the fate of formulated inhalation compounds delivered to the lung, a model of the airway epithelium should reflect drug permeability and transport characteristics in vivo. Most cell-based system established for this purpose, study drug transport using wet models and thus do not necessarily represent in vivo conditions. Recently, air-interface models have been established ...

Prior studies have shown the retinoid X receptor (RXR) agonist bexarotene has preventive efficacy in rodent models of mammary and lung tumorigenesis albeit causing hypertriglyceridemia and hypercholesterolemia. We reasoned that bexarotene delivered by inhalation may provide sufficient dose directly to the respiratory tract to achieve efficacy while avoiding these side effects. In this study, th...