BACKGROUND/AIM Plumbago indica (PI) L. and its active constituent, plumbagin, has been traditionally claimed for several pharmacological activities; however, there is little information regarding their toxicity. The present study aims to examine the effects of plumbagin and PI extract (PI) on hepatic histomorphology and antioxidative system in mice. MATERIALS AND METHODS Adult male intelligen...

One of the molecular mechanisms of alcohol induced toxicities is mediated by oxidative stress. Hence our studies were focused on the effect of thiamine (antioxidant) in the reversal of alcohol induced toxicity and comparison of the reversal with abstinence. Administration of ethanol at a dose of 4 g/kg body wt/day for 90 days to Sprague Dawley rats manifested chronic alcohol induced toxicity ev...

The present investigation explores the possibilities of using the root and leaf extracts of an important plant Withania somnifera targeting DM and to examine their hypoglycaemic and hypolipidaemic effects on Streptozotocin-induced diabetic rats. Withania somnifera root extracts (WSREt) and leaf extracts (WSLEt) were orally administered daily to diabetic rats for eight weeks. After the treatment...

The liver enzymes, alanine transaminase (ALT) or aspartate transaminase (AST), are commonly used in clinical practice as screening as well as diagnostic tests for liver diseases. ALT is more specific for liver injury than AST and has been shown to be a good predictor of liver related and all-cause mortality. Asymptomatic mild hypertransaminasemia (i.e., less than five times normal) is a common ...

OBJECTIVE To investigate the effect of coffee consumption on some liver function indices in adult male and female Nigerians. SUBJECTS AND METHODS Thirty apparently healthy subjects, consisting of 18 men and 12 women, were made to consume 2 g of coffee daily for a total of 30 days. Activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and plasma con...

Aim: In this study, sub-acute toxicity of deltamethrin on hematological and biochemical blood parameters of male albino Swiss mice was evaluated. Materials and Methods: Generally, the maximum permissible residue level (MRL) of deltamethrin for food products lies between 0.01 to 0.5 mg/kg body weight. So the mice were exposed orally with two doses of pesticide i.e. 0.1 and 0.5 mg/kg body weight....

BACKGROUND Hypercholesterolemia is a condition characterised with high level of cholesterol in the blood. OBJECTIVES The effect of ethanolic extract of Buchholzia coriacea (EEBC) on the lipid profile levels and extent of lipid peroxidation in hypercholesterolemic albino rats was investigated in this study. METHODS Thirty albino rats were divided into six different groups which consist of gr...

OBJECTIVE To evaluate the hepatoprotective properties of Otostegia persica (O. persica) ethanol extract on carbon tetrachloride-induced liver damage in rats. MATERIALS AND METHODS Fifty adult male Wistar rats were randomly divided into five groups. Group I served as normal control and was given only olive oil intraperitoneally (i.p.). Group II, III, IV, and V were administered CCl4 mixed with...

BACKGROUND Liver enzyme abnormalities have been reported in Turner's syndrome (TS). There are some studies about possible causes of abnormal levels of liver enzymes. One of the main suggestions is obesity. The study aimed to determine the relationship between obesity and liver enzymes levels in patients with TS. METHODS Forty-one karyotype-proven TS patients referred to Endocrinology and Meta...

At present, a great deal of attention is being focused on the tortoise as a domestic pet. Knowledge of the blood biochemical parameters in captivity of this animal would be helpful for evaluations of their health. In this regard, the serum biochemical values were measured in 12 Asian tortoises (6 males and 6 females) before hibernation. Serum values of total protein (TOP) 63.19 ± 7.57 g/L, Alb...