purpose : to determine the maximum non-toxic dose of recombinant human erythropoietin (epo) in rabbit eyes methods : eight rabbits (sixteen eyes) were scheduled for evaluating side effects of four intravitreal doses of 1000, 2000, 4000 and 5000 iu of epo, two rabbits for each dose. for each dose (two rabbits), the drug was injected for the right eyes. balanced salt solution (bss) was injected i...

tendon never restores the complete biological and mechanical properties after healing. bone marrow and recently adipose tissue have been used as the sources of mesenchymal stem cells, which have been proven to enhance tendon healing. stromal vascular fraction (svf), derived from adipose tissue by an enzymatic digestion, represents an alternative source of multipotent cells, which undergo differ...

there is documented evidence that infection in laboratory animals can often influence the outcome of experiments. all infections, apparent or inapparent, are likely to increase biological variability. as a research project concerning the diversity and distribution of parasites of rabbit and guinea pig in a conventional laboratory animal house, about 87 rabbits (from 700 ) and 105 guinea pigs (f...

A linear relationship exists in the albino rat between the heart weight and the basal metabolic rate when varied by the administration of active thyroid material. It is suggested that this increase in heart weight which follows the increase in metabolism after thyroid is in the nature of a simple work hypertrophy of the myocardium.

Rabbits are animals prone to diseases, mainly affected by digestive system conditions. According the author's experience, interviews with rabbit breeders and veterinarians were located in Tangerang, if disorders do not receive proper treatment will quickly result death for rabbit. Rabbit owners sometimes don't know what do. Obstacles often encountered limited time, costs, number of who still sm...

PURPOSE Ripasudil is a novel Rho-associated protein kinase inhibitor that is used to treat ocular hypertension. However, the comparison of the intraocular pressure (IOP)-lowering effects between ripasudil alone and other ocular hypotensive drugs has not been studied thoroughly. The purpose of this study is to examine the ocular hypotensive effects of 0.4% ripasudil, 2% pilocarpine, 0.5% timolol...

In mammals, passive immunity is transferred from mother to offspring by transplacental passage or by intestinal absorption . The rabbit receives antibodies exclusively across the placenta, whereas intestinal absorption is the principal source of antibodies for the newborn pig. In the rat, passive immunity is transferred by both pathways . The role of the jejunal absorptive cells was investigate...

dorzolamide ophthalmic drop is one of the most common glaucoma medications but it has a short residence time in the eye. the aim of this study is to develop ocular dorzolamide hcl nanoliposomes (drz – nanoliposomes) and to evaluate their potential use for the treatment of ocular hypertension. nanoliposomes were prepared using reverse-phase evaporation vesicle (rev) and thin layer hydration (tlh...

Dorzolamide ophthalmic drop is one of the most common glaucoma medications but it has a short residence time in the eye. The aim of this study is to develop ocular dorzolamide HCl nanoliposomes (DRZ – nanoliposomes) and to evaluate their potential use for the treatment of ocular hypertension. Nanoliposomes were prepared using Reverse-phase evaporation vesicle (REV) and thin layer hydration (TLH...

In order to determine the effects of intraocular 0.05% povidone-iodine preparation in the prevention of bacterial endophthalmitis in a rabbit model, 28 albino rabbits were randomly assigned to 4 equal groups. A concentration of 5x 108 organisms (0.03 mL) in logarithmic growth phase of S. epidermidis, S. aureus, Proteus mirabilis and Pseudomonas aeruginosa, were injected separately in the a...