in the present study, free-radical-scavenging and antioxidant activities of angipars™, an herbal extract which has been registered as a therapeutic drug for diabetic foot ulcer, were examined. we investigated the protective effect of angipars™ on cytotoxicity produced by exposure to h2o2 (300 µm) in hepg2 and a549 cell lines, using mtt assay, glutathione (gsh) content analysis, and lipid peroxi...

background: melatonin is a free radical scavenger. it has also antioxidant effects through its stimulatory actions on antioxidant system. objective: we conducted this study to examine the effect of different oral doses of melatonin on liver tissue. methods: we used 42 rats—6 rats in each group. group i served as the control group; group ii rats were pretreated with only melatonin; group iii was...

Selenium, because of its affinity for SH/SS, thiol group, offers protection against or detoxifies mercury in marine vertebrates. This study explores the possibility of a similar effect for a marine invertebrate. Arcid blood clams Anadara granosa (L.) with erythrocytic haemoglob~n were exposed to sublethal concentrations of ~ g ' + (0.1 mg I-', as HgCI2), Se4+ (1.0 mg I' , SeO?) and reduced glut...

The aim of study is to reduce hepatic damage from paracetamol will be funded using alcohol extract for ginger and vitamin E as antioxidants in male New Zealand rabbits. Paracetamol (acetaminophen) a widely used over-the-counter analgesic antipyretic drug which known cause liver injuries both humans experimental animals when administered overdose. current was conducted at the animal house Colleg...

objective: ionizing radiation interacts with biological systems to induce excessive fluxes of free radicals that attack various cellular components. melatonin has been shown to be a direct free radical scavenger and indirect antioxidant via its stimulatory actions on the antioxidant system.the aim of this study was to evaluate the antioxidant role of melatonin against radiation-induced oxidativ...

The major risk factor for melioidosis, an infectious disease caused by B. pseudomallei, is diabetes mellitus. More than half of diabetic melioidosis patients in Thailand were prescribed glibenclamide. Recent evidence demonstrates that glibenclamide reduces pro-inflammatory cytokine production by polymorphonuclear neutrophils (PMNs) of diabetic individuals in response to this bacterial infection...

Reactive oxygen species (ROS) are by-products of the cellular metabolism of oxygen consumption, produced mainly in the mitochondria. ROS are known to be highly reactive ions or free radicals containing oxygen that impair redox homeostasis and cellular functions, leading to cell death. Under physiological conditions, a variety of antioxidant systems scavenge ROS to maintain the intracellular red...

Using isolated, in situ, single-pass perfused rat livers, incubations of freshly isolated hepatocytes, and sinusoidal membrane-enriched vesicles, we and others have shown the saturability of transport (efflux) of hepatic glutathione (GSH). These observations have implicated a carrier mechanism. Our present studies were designed to provide further evidence in support of a carrier mechanism for h...

In the present study, oxidative damage parameters in preeclamptic pregnant women were investigated and compared with healthy tissues. Antioxidant enzymes determined 53 placentas. The of free oxygen radicals placental tissue was by measuring antioxidant enzyme systems (The amounts lipid peroxidation (LPO), glutathione (GSH) catalase (CAT), myeloperoxidase (MPx) activities nitric oxide levels (NO...