Most anaesthetists would agree that there is room for a more satisfactory intravenous anaesthetic than thiopentone. This drug is a powerful depressor both of blood pressure and of respiration. The compound G.29.505 was investigated in the laboratory by Thuillier and Domenjoz (1957), and appeared to offer some promise, particularly because of some tendency on its part to stimulate respiration. F...

A pivotal scene in the 2019 reinvention of Bill Forsyth’s 1983 film Local Hero into musical theatre involves a hangover[...]

Abstract The aim of the study was to investigate effect voluntary employer changes on self-reported work ability among older workers in Germany and whether a honeymoon-hangover (HHE) exists here. In research job satisfaction, three typical periods around change characterize HHE: deterioration old (deterioration), an initial increase new (honeymoon) subsequent decline over time (hangover). Wheth...

AIM To estimate the prevalence of hazardous drinking and its socio-economic distribution among Russian men. DESIGN Participants were an age-stratified, population-based random sample of men aged 25-54 years living in Izhevsk, a city in the Urals, Russia. Interviewers administered questionnaires to cohabiting proxy respondents about behavioural indicators of hazardous drinking derived from fre...

BACKGROUND There are robust sex differences for alcohol phenotypes, with men reporting more drinking and alcohol use disorder (AUD) symptoms than women. However, the sources of these effects are not completely understood. Sex hormones, a substantial biological sex difference, exert neurobehavioral influences and are candidates for influencing sex differences in alcohol phenotypes. This study in...