The human aldo-keto reductase AKR1B10, originally identified as an aldose reductase-like protein and human small intestine aldose reductase, is a cytosolic NADPH-dependent reductase that metabolizes a variety of endogenous compounds, such as aromatic and aliphatic aldehydes and dicarbonyl compounds, and some drug ketones. The enzyme is highly expressed in solid tumors of several tissues includi...

Review of literature shows that large varieties of compounds have been found to bear hypoglycemic action. For instance, glycosides afford active principles that lower blood sugar in test animals. Following the I.V. administration of a 4 percent decoction of the dried T. polium herb, a definite reduction of blood sugar level has been exhibited. With reference to PDR for Herbal Medicines for the ...

Review of literature shows that large varieties of compounds have been found to bear hypoglycemic action. For instance, glycosides afford active principles that lower blood sugar in test animals. Following the I.V. administration of a 4 percent decoction of the dried T. polium herb, a definite reduction of blood sugar level has been exhibited. With reference to PDR for Herbal Medicines for the ...

Exposure of the lens of the eye to a high concentration of an aldose, such as n-glucose, n-galactose, or n-xylose, results in the accumulation of the corresponding sugar alcohols. The high concentration which t.hese alcohols reach within the lens fibers appears to be responsible for t,he loss of clarity of the lens that is observed in experimental sugar cataracts (1). The reduced triphosphopyri...

Introduction Aldose reductase (AR2) is a 37 kDa protein found in human erythrocytes and lenses of various species (see refs. [l-31 for reviews). It has been suggested that the protein is one of the NADPH-dependent monomeric aldehyde reductases present in many mammalian tissues [4], although the proteins from this ‘family’ do not cross-react immunochemically [5,6]. AR2 is therefore not identical...

We evaluated the inhibitory effects of components from the root of Glycyrrhiza uralensis (G. uralensis) on aldose reductase (AR) and sorbitol formation in rat lenses with high levels of glucose as part of our ongoing search of natural sources for therapeutic and preventive agents for diabetic complications. In order to identify the bioactive components of G. uralensis, 5 prenylated flavonoids (...