Allergy to proteins and glycoproteins from animal sources is an important public health problem affecting both children and adults (1–3). Exposure to animal allergens is a key factor for the development of allergy, particularly for the development of allergic airway diseases such as asthma and rhinitis (4, 5). Among the many particles and molecules of animal origin present in our environment, s...

Recombinant allergens are a promising alternative to crude allergen extracts for diagnosis and therapy of allergic diseases. Genetically modified allergen derivatives with reduced allergenic activity but retaining their immunogenicity have also been produced to increase safety and specificity of allergen-specific immunotherapy. When a limited number of allergens are responsible for most of the ...

227 Changing Scenario of Airborne Allergens in Bangalore, India Anand Pendakur, MBBS, DLO and Balaji Ramdas, MBBS. Allergy Asthma ENT Clinic, Indian College of Allergy Asthma and Applied Immunology, Bangalore, India; Community Medicine, Indian Academy of Allergy, Bangalore, India. With phenomenal growth of Bangalore city and a distinct shift of its arboriculture in the last 2 decades, change in...

Background: Asthma is the most common chronic disease of childhood. Exposure to allergens plays an important role in asthma. Recently, cockroach has attracted attentions as an important allergen. Objective: To evaluate cockroach allergy in Iranian children with asthma. Methods: 100 children with asthma were studied. After determination of asthma severity, serum total IgE and blood eosinophils w...

Background and aim: The frequency of sensitization to contact allergens varies in different countries because of both genetic and, more importantly, allergen exposure variations. The objective is to determine the frequency of sensitization to contact allergens in Iranian patients with dermatitis.Materials and methods: Four hundreds and one patients with a clinical diagn...

Background Panallergens (profilins, polcalcins and non-specific lipid transfer proteins) are responsible for polysensitization to various allergens including pollen and food allergens in a number of individuals which might account for a problem in distinguishing between true allergy from cross reactivity in allergy testing. A broad range of pollenand plant-derived allergens contain profilins an...

Identification, characterization, and purification of allergens are essential for the structural and immunologic studies needed to understand how these molecules induce specific IgE antibody production by the human immune system. Advances in molecular biology techniques have led to the production of recombinant allergens having constant properties, allowing detection of specific IgE directed ag...

The years 1988-1995 witnessed the beginning of allergen cloning and the generation of recombinant allergens, which opened up new avenues for the diagnosis and research of human allergic diseases. Most crystal and solution structures of allergens have been obtained using recombinant allergens. Structural information on allergens allows insights into their evolutionary biology, illustrates clinic...

BACKGROUND Grass pollen is one of the most important allergen sources. The aim of this study was to compare the in vivo allergenic activity of two recently characterized major grass pollen allergens, Phl p 4 and Phl p 13, with three established major grass pollen allergens, Phl p 1, Phl p 2 and Phl p 5 as a basis for the formulation of a grass pollen allergy vaccine based on purified allergens....