Aim: The objective of this research is to highlight the effectiveness physical exercise and music therapy in older patients with Alzheimer’s disease (AD). Methods: Patients a mild level AD were included study, divided into group (TG; N = 30, aged 68 ± 3.2 years) control (CG; N=30, 65 2.6 years). was enrolled an exercise-training program (walking, resistance balance exercises) combined musical f...

In order to assess their destination memory, sixteen patients with probable mild Alzheimer Disease (AD), sixteen older adults and 16 young adults were asked to tell facts to pictures. On a subsequent task, they were asked to remember whether they had previously told that fact to that face or not. AD patients showed poorer destination recall than the older adults, and the older adults showed poo...

Alzheimer disease is the most common form of dementia and has a significant impact on mortality in the senior population. A vast amount of information has emerged over the past decade especially in regards to the underlying genetics and the significance of intrinsic and extrinsic risk factors. The importance of identifying risk factors may provide critical information to prioritize those patien...

BACKGROUND Neurochemical and pathologic studies show that mild cognitive impairment (MCI) is frequently a transitional state between normal aging and Alzheimer disease (AD). Neuropathologic sample sizes have been limited because relatively few individuals with MCI die before dementia develops. Decreased neocortical nicotinic receptor binding is characteristic of AD but has not been investigated...

BACKGROUND Factors that modify risk related to APOE variants have been examined primarily in unrelated patients and controls, but seldom in family-based studies. Stroke, vascular risk factors, estrogen replacement therapy (ERT), head injury (HI), and smoking have been reported to influence risk of sporadic but not familial Alzheimer disease (AD). OBJECTIVES To examine the potential relationsh...

CONTEXT The hallmark pathological changes in Alzheimer disease (AD) are abundant plaque and tangle formation, especially in the temporal lobes and hippocampus. Although there is increasing evidence that major depression may interact with neuropathological processes in AD, there have been no studies of neuropathological changes in AD as a function of history of major depression. OBJECTIVE To t...

OBJECTIVE To delineate the trajectories of Aβ42 level in cerebrospinal fluid (CSF), fludeoxyglucose F18 (FDG) uptake using positron emission tomography, and hippocampal volume using magnetic resonance imaging and their relative associations with cognitive change at different stages in aging and Alzheimer disease (AD). DESIGN Cohort study. SETTING The 59 study sites for the Alzheimer's Disea...

Background: Alzheimer Disease (AD) is an age-related neurodegenerative disorder with a progressive impairment of cognitive function. The pineal gland hormone melatonin (MEL) has been known as a protection agent against AD. However, the effect of melatonin in various doses is inconsistent. Objectives: In this study, we aimed to investigate two doses of MEL on learning and memory in the amyl...

alzheimer's disease (ad), a common and debilitating neurodegenerative disorder, affect more than 65 million individuals throughout the world. this disability plays a crucial role in daily activities such as driving. several studies have investigated the relationship between cognitive functions and driving safety. the current study revises the literature on the relation between road safety ...

Background In 2018, the National Institute of Aging and Alzheimer Association proposed a purely biological definition Alzheimer’s disease (AD) relying on biomarkers. While intended use framework was for research purposes, it has engendered debate challenges regarding its application in everyday clinical practice. For instance, cognitively unimpaired individuals may have biomarker evidence both ...