By the virtual screening method we have screened out Dihydrochalcone as a top-lead for the Alzheimer's disease using the database of about 32364 natural compounds. The binding affinity of this ligand to amyloid beta (Aβ) fibril has been thoroughly studied by computer simulation and experiment. Using the Thioflavin T (ThT) assay we have obtained the inhibition constant IC50 μM. This result is in...

Bentham Science - STM publisher of online and print journals, related print/online book series. answers the information needs scientists in fields pharmaceutical, biomedical, medical, engineering, technology, computer social sciences.

BACKGROUND: The aging of the worlds population leads to an increase in prevalence age-related diseases, including cognitive impairment. At stage dementia, therapeutic interventions become usually ineffective. Therefore, researchers and clinical practitioners today are looking for methods that allow early diagnosis impairment, techniques based on use biological markers.
 AIM: aim this liter...