Currently: the problem of choosing an effective drug approach for cerebroprotection, in case traumatic brain injury (TBI), remains to be poorly understood. Clinical studies cerebroprotectors - antagonists NMDA-receptors indicate feasibility their use practice. In our opinion, further research, it would correct choose a compound that has neuroprotective properties and synthesized under guidance ...

previous studies have shown antiviral effect of echinacea and elderberry preparations against human influenza viruses in vitro. to investigate the in vivo antiviral effect of these herbs on avian h9n2 influenza virus, amantadine and two standardized commercial extracts of echinacea purpurea (ef) and sambucus nigra (sam) were used in broiler chickens infected with h9n2 strain of the virus. ef, s...

Amantadine and rimantadine hydrochloride were tested for stability after storage at different temperatures and under different conditions for extended periods of time. Both compounds were quite stable after storage for at least 25 years at ambient temperature; they both retained full antiviral activity after long-term storage or after boiling and holding at 65-85 degrees C for several days. Thu...

Levodopa-induced dyskinesia (LID) is one of the most common and frequently dose-limiting complications of pharmacologic therapy for Parkinson disease (PD). These typically choreiform movements, usually occurring at the time of peak levodopa effect, occur in 40% to 50% of patients after 5 years of therapy but have a reported incidence as high as 94% in a carefully conducted prospective study of ...

Recent studies have shown that NMDA receptors are involved in the tolerance and dependence to opioids. In addition, it has been reported that ketamine, dextromethorphan and amantadine have antagonistic activity at NMDA receptors. Therefore, this study was conducted to clarify the effect of these drugs on morphine withdrawal syndrome. Morphine dependence was induced by increasing doses of morphi...

In a previous study, we10 addressed ourselves to the question of whether amantadine was effective in the treatment of Parkinson's disease. By qualitative and quantitative criteria, amantadine ( Symmetrel) was found to be a safe and effective agent, with specific improvement occurring in tests involving gait, coordination, strength, and more complex activities of daily living. We here report a c...