Background and Objectives. White adipose tissue (WAT) shows marked sex- and diet-dependent differences. However, our metabolic knowledge of WAT, especially on amino acid metabolism, is considerably limited. In the present study, we compared the influence of sex on the amino acid metabolism profile of the four main WAT sites, focused on the paths related to ammonium handling and the urea cycle, ...

The aim of the present research is to investigate the profile of amino acid of Chlorella vulgaris supplemented with some plant amino acid and oil extracts. The bioactive oil and amino acid from four Iranian medicinal plants, namely Oliveria decumbens, Thymus kotschyanus, Trachyspermum ammi, and Zataria multiflora were obtained. The LC-MS / MS analysis demonstrated that the major amino acids com...

An association between sulfur amino acids (methionine, cysteine, homocysteine and taurine) and lipid metabolism has been described in several experimental and population-based studies. Changes in the metabolism of these amino acids influence serum lipoprotein concentrations, although the underlying mechanisms are still poorly understood. However, recent evidence has suggested that the enzyme st...

It is well known that lactic acid bacteria need multiple nutritional requirements for growth. They require numerous amino acids and other growth factors to develop in synthetic media. In this review the amino acid requirements, the effect of L-malic acid and citric acids metabolism on these requirements and the catabolism of amino acids by lactic acid bacteria from wine are discussed, with emph...

Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood. Here we describe a role for asparagine as an amino acid exchange factor: intracellular asparagine exchanges with extracellular amino acids. Through asparagine synthetase knockdown and altering of media asparagine concentration...

Coprinus comatus polysaccharide (CCP) has significant hepatoprotective effect. To explore mechanism of CCP, the study analyzed preventive effect CCP on acute alcoholic liver injury in mice by histopathological examination and biochemical analysis. Simultaneously, was also conjunction with metabolomics proliferation gut microbiota. The results showed that significantly decreased alanine a...

Chronic myelogenous leukemia (CML) stem cells are the cellular source of vast majority mature CML and responsible for relapse disease post-tyrosine kinase inhibitor (TKI) therapy. Although cells, whose active division is driven by BCR-ABL1 oncogene-dependent signaling, reduced TKI therapy, resistant because they become quiescent via a heretofore elusive mechanism that independent oncogene signa...