Nitrosation reactions of amino acids with an -NH(2) group [namely, six alpha-amino acids (glycine, alanine, alpha-aminobutyric acid, alpha-aminoisobutyric acid, valine, and norvaline); two beta-amino acids (beta-alanine and beta-aminobutyric acid), and one gamma-amino acid (gamma-aminobutyric acid)] were studied. Nitrosation was carried out in aqueous acid media, mimicking the conditions of the...

Gamma-aminobutyric acid is an important nonprotein amino and has been extensively applied in pharmaceuticals, livestock, food additives, so on. It to develop Corynebacterium glutamicum strains that can efficiently produce gamma-aminobutyric from glucose. In this study, production of C. CGY700 was improved by construction CO2 anaplerotic reaction overexpression citrate synthase. The co-expressio...

Tryptophan (TRP) is the precursor of melatonin, the primary secretory product of the pineal gland. Hepatic heme deficiency decreases the activity of liver tryptophan pyrrolase, leading to increased plasma TRP and serotonin. As a paradox, patients with attacks of acute intermittent porphyria (AIP), exhibit low nocturnal plasma melatonin levels. This study using a rat experimental model was desig...

Accumulation of γ -aminobutyric acid (GABA) is associated with stress factors in plant systems. The objective of the current study was to compare GABA concentration in wheat plants under chilling stress. After 48 h treatments of seedlings under chilling stress combined stresses with and without GABA, morphological and biochemical assays were conducted. It was observed that the inhibition of see...

BACKGROUND Prenatal protein malnutrition disrupts the pattern of maturation and development of the hippocampus and its neuroanatomy and increases inhibition of the granular cell layer of the fascia dentata. If local gamma-aminobutyric acid inter-neurons are partly responsible for inhibition of the hippocampus, it is reasonable to assume that there may be an increase in the gamma-aminobutyric ac...