The reaction of phenyl acetate with pyrazole is catalyzed by general bases and by bifunctional general acids. The Br~lnsted plot for general base catalysis shows downward curvature. It is consistent with either a Hammond effect on proton transfer, as described by a positive coefficient p x = a/3/-apKAH, or separate lines with p = 0.65 for cacodylate and substituted acetate monoanions and /3 = 0...

?-hydroxylamines exhibit higher reactivity toward cyclic carbonates compare to regular amines and allowed access fully biobased polyhydroxyurethanes.

Proteins, as their name indicates, occupy the prime place in Nature’s architecture. I t is worth remarking th a t Nature uses the structural type for diverse purposes, in addition to those familiar in enzymology, immunology, etc. A striking example is provided by the recent publication (Bradbury et al. 1976), showing tha t the C fragment of lipotropin (residues 6191) is firmly bound by opiate r...