Centrally active muscarinic agonists display pronounced analgesic effects. Identification of the specific muscarinic acetylcholine receptor (mAChR) subtype(s) mediating this activity is of considerable therapeutic interest. To examine the roles of the M(2) and M(4) receptor subtypes, the two G(i)/G(o)-coupled mAChRs, in mediating agonist-dependent antinociception, we generated a mutant mouse li...

The present study was carried out to investigate the analgesic, anti-inflammatory, antibacterial and antifungal properties of ethanol leave extract of Mangifera indica. For evaluation of analgesic and anti-inflammatory properties, acetic acid induced writhing response model and carrageenan induced paw edema model were used in Swiss albino mice and Wistar albino rats, respectively. In both cases...

extracts obtained from the aerial parts of stachys lavandulifolia (lamiaceae) are used in iranian folk medicine as remedies for the treatment of various painful and inflammatory diseases. for evaluation of its probable analgesic and anti-inflammatory effects, hydroalcoholic, polyphenolic and boiled extracts of the aerial parts of the herb were prepared and their analgesic effects were studied i...

In the present study, the crude methanolic extract of whole plant part of Blumea membranacea (Asteraceae) and its fractions obtained by Kupchan method were screened for their possible analgesic, cytotoxic and antioxidant activities. The analgesic activity of the samples was evaluated using acetic acid induced writhing method in Swiss-albino mice. In this method, acetic acid is administered intr...

OBJECTIVES The study was carried out to assess the analgesic, anti-inflammatory, and CNS depressant activity of the methanolic extract of the Lawsonia inermis barks (MELIB). MATERIALS AND METHODS Anti-inflammatory effects of MEBLI were studied using carrageenan-induced inflammatory method at the dose of 300 and 500 mg/kg b.wt., p.o. Analgesic activity was measured using acetic acid-induced wr...

The aqueous extract of Parsley ( Petroselinum crispum ) were investigated for anti-inflammatory, analgesic and antipyretic activity at the doses of 2 , 5 , and 10 g/kg, of body weight. The experimental paradigms used were carrageenan, dextran, histamine induced pedal edema and cotton pellet induced granuloma for anti-inflammatory activity, while hot plate and acetic acid induced writhing method...

A series of 1-phenyl-3-(2-{substituted-phenylhydrazono})-indolin-2-one derivatives (IIa-k) were synthesized. The compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and antimicrobial actions. Among the tested compounds, two compounds IIf and IIk showed higher degree of anti-inflammatory activity (>75% activity of standard indomethacin). These compounds were further test...

Investigation of central nervous system activity of phenylcyclohexylamines was continued by preparation of "reversed" analogues. Following the unexpected finding of analgesic activity with 1-(dimethylamino)-1-phenylcyclohexylamine, the SAR of the series was investigated. Synthesis starts by double Michael reaction of acrylate on arylacetonitriles. Following cyclization, decarboxylation, ketaliz...

Physalis minima Linn. (Family  Solanaceae) is commonly known as Ground Cherry or Sunberry. It is traditionally used as diuretic, purgative, analgesic, anthelmentic, febrifuge, vermifuge, abortificient, etc. Many steroidal lactones have been identified from the plant and it has been reported to possess antifertility, hypoglycemic, cytotoxic, antiulcer, antibacterial, anti-inflammatory, analgesi...

Inflammation is all a pervasive phenomenon, which is elicited by the body in response to obnoxious stimuli as a protective measure. However, sustained inflammation leads to several diseases including cancer. Therefore it is necessary to neutralize inflammation. Sonapatha (Oroxylum indicum), a medicinal plant, is traditionally used as a medicine in Ayurveda and other folk systems of medicine. It...