BACKGROUND AND OBJECTIVES Esmolol is known to have no analgesic activity and no anaesthetic properties; however, it could potentiate the reduction in anaesthetic requirements and reduce postoperative analgesic use. The objective of this study is to evaluate the effect of intravenous esmolol infusion on intraoperative and postoperative analgesic consumptions as well as its effect on depth of ana...

Opioids are commonly used as effective analgesics for the treatment of acute and chronic pain. However, considerable individual differences have been widely observed in sensitivity to opioid analgesics. We focused on a G-protein-activated inwardly rectifying potassium (GIRK) channel subunit, GIRK2, that is an important molecule in opioid transmission. In our initial polymorphism search, a total...

This study was designed to test the hypothesis whether preemptive administration of rofecoxib, a novel selective COX-2 inhibitor, can prolong intraarticular bupivacaine analgesia after arthroscopic knee surgery. Sixty-two patients were randomly assigned to one of the three groups. Group 1 (n=21) was administered oral rofecoxib 50 mg 1 h before surgery plus intraarticular 0.5 % bupivacaine 20 ml...

BACKGROUND In this double-blind, randomized, placebo-controlled study, we evaluated the effects of magnesium sulphate on neuromuscular blocking agent requirements and analgesia in children with cerebral palsy (CP). METHODS We randomly divided 61 children with CP undergoing orthopaedic surgery into two groups. The magnesium group (Group M) received magnesium sulphate 50 mg kg(-1) i.v. as a bol...

As healthcare practitioners continue to search for multimodal analgesic therapies reduce postoperative opioid requirements, surgical ward nurses need stay up date on the status of emerging therapies. One these is intravenous lidocaine pain management. Unfortunately, there a lack resources assist who are unfamiliar with infusions pain. This article aims review pharmacology management, describe a...

background pain following laparoscopy could be due to different causes requiring effective postoperative analgesia. objectives in the present study, we evaluated the combined effect of intraperitoneal infiltration of bupivacaine-meperidine versus intravenous infusion of paracetamol on pain relief after diagnostic gynecologic laparoscopy. conclusions intraperitoneal infiltration of bupivacaine w...

background: b vitamins deficiencies in humans and animals have been known for some time to induce pain and inflammation. these symptoms can be readily alleviated by appropriate administration of vitamins b. the aim of this study was to evaluate opioids requirements and hemodynamic variables and analgesic effect of b vitamins and b vitamins-diclofenac in general anesthesia and post-anesthesia ca...

T WO factors have increased interest in ketamine for postoperative analgesia. The first was the discovery of the N-Methyl-D-asparrate (NMDA) receptor and its role in central pain processing and spinal cord neural plasticity. 1 Ketamine is one of two clinically useful NMDA receptor antagonists available (the other is dextromethorphan). Ketamine binds non-competitively to the PCI, (phencyclidine)...