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This vignette introduces the use of the Bioconductor package DSS (Dispersion Shrinkage for Sequencing data), which is designed for differential analysis based on high-throughput sequencing data. It performs differential expression analyses for RNA-seq, and differential methylation analyses for bisulfite sequencing (BS-seq) data. The core of DSS is a procedure based on Bayesian hierarchical mode...
The debate on people’s right to privacy and on the meaning of privacy is ongoing worldwide, for example in Europe over the newly adopted General Data Protection Regulation. By contrast, works in the area of formal e-voting privacy analysis, which aim at assessing the privacy preservation of a target e-voting system by means of mathematical rigour, appear to have reached a well-known plateau. Th...
UNLABELLED Recent studies have unveiled discrete block-like structures of linkage disequilibrium (LD) in the human genome. We have developed a set of computer programs to analyze the block-like LD structures (haplotype blocks) based on haplotype data. Three definitions of haplotype block are supported, including minimal LD range, no historic recombination, and chromosome coverage. Tagged SNPs t...
THE CENTRALITY OF LEARNING TO CHILDREN’S DEVELOPMENT 464 History 465 MICROGENETIC METHODS FOR STUDYING LEARNING 469 Essential Properties 469 Applicability 469 History 471 Methodological Issues 472 OVERLAPPING WAVES THEORY 477 THE NEW FIELD OF CHILDREN’S LEARNING 480 Variability 480 Basic Empirical Phenomena 480 Inf luences of Child and Environment 484 Theoretical Implications and Questions 486 ...
A review is given on the present status of precision tests of the Standard Model and of the Minimal Supersymmetric Standard Model (MSSM), including a discussion of the implications for the mass of virtual heavy particles via quantum effects. Expectations for high-precision analyses at future hadron and electron-positron colliders are also presented.
In the enormous collection of cross-cultural data that have been published during the last few decades it is difficult to perceive patterns. There is a clear need for systematizing the vast amount of cross-cultural studies and for developing models that explain cross-cultural differences in psychology. Two methods of crosscultural meta-analysis can be distinguished. First, the instrument-based ...
The criteria for the admission of patients to the Medical Research Council's (MRC) myeloma trials are the finding of abnormal plasma cells in bone marrow films or sections and in addition either of characteristic skeletal lesions demonstrated radiologically or of characteristic protein changes in the serum or urine. Ninety per cent of the patients in the first myeloma trial satisfied all three ...
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