BACKGROUND Dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibition offers an attractive therapeutic strategy in anaplastic large cell lymphoma depending on oncogenic nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) signaling. We tested the efficacy of a novel dual PI3K/mTOR inhibitor, NVP-BGT226 (BGT226), in two anaplastic large cell lymphoma cell lines in vi...

  Background and Objectives: Classic Hodgkin lymphoma (CHL), anaplastic large cell lymphoma (ALCL) and some cases of diffuse large B cell lymphoma (DLBCL) have overlapping morphologic features. Since they all represent distinct clinico-pathologic entities, we explored the differential diagnostic impact of immunophenotyping to discriminate between them. Materials and Methods:...

The anaplastic lymphoma kinase (ALK) gene is expressed in.50% of anaplastic large-cell lymphomas (ALCLs). Although most patients withALK-positiveALCL respondwell to anthracycline-based chemotherapy, relapses do occur (5-year failure-free survival 60%) and require salvage therapy, generally with poor outcomes. Autologous stem cell transplant is an option in the salvage setting, but not all patie...

We report the case of a 66-year-old man who consulted with a 3-week history of a rapidly growing asymptomatic lesion on his left cheek that for the previous week had prevented him from opening the eye on that side (Fig. 1). Two years earlier at another center the patient had been diagnosed with a primary systemic CD30 anaplastic large-cell lymphoma (ALCL), with skin lesions in the same area as ...

Inflammatory myofibroblastic tumour (IMT) is a rare neoplasm which can affect many different organs throughout the body. We report the case of a 62-year old female presenting with visible haematuria found to have IMT of the urinary bladder exhibiting anaplastic lymphoma kinase-1 gene rearrangement, initially managed with local resection and then definitively with partial cystectomy.

the embryo, consistent with a shared origin of these cell-types. We also present evidence that iridophore precursors are likely to also have glial potential. Finally, we engineered constitutively active form of ltk gene by analogy with oncogenic gene nucleophosmin-anaplastic lymphoma kinase, and examine the results from experiments asking what happens to NCCs with constitutively active Ltk sign...

A new mechanistic principle for reporting the phosphorylation of tyrosine is described, which should prove applicable to even the most fastidious of protein tyrosine kinases, as demonstrated by the acquisition of a fluorescent sensor for the extraordinarily demanding anaplastic lymphoma kinase.