OBJECTIVE To investigate whether there is an association between use of ACE inhibitors (ACEI) and angiotensin receptor blockers (ARB) and risk of acute kidney injury (AKI). STUDY DESIGN We conducted a new-user cohort study of the rate of AKI among users of common antihypertensives. SETTING UK primary care practices contributing to the Clinical Practice Research Datalink (CPRD) eligible for ...

BACKGROUND Previous studies have shown that a higher resistive index (RI) on renal duplex ultrasonography was related with renal progression and acute kidney injury, especially in patients with chronic kidney disease (CKD) using an angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor antagonist (ARB). We evaluated whether a RI value is a predictive factor for renal progression...

OBJECTIVE Permeability of blood vessels is essential for tissue homeostasis. However, disorganized hyperpermeability leads to progression of diseases. Vascular endothelial growth factor-A (VEGF) is a key regulator for leakiness of blood vessels and it has been reported that VEGF-mediated hyperpermeability was suppressed by angiopoietin-1 (Ang1). We found that Angiotensin-converting enzyme (ACE)...

Purpose Dysfunction of the renin-angiotensin system (RAS) contributes to pathogenesis of diabetic retinopathy (DR). Yet RAS blockers have only limited beneficial effects on progression of DR in clinical trials. The natriuretic peptide system offsets RAS, so that enhancing the activity of this system on top of RAS blockade might be beneficial. Neprilysin has an important role in the degradation ...

We read with interest the study by Johnson et al. (1). We believe that one of the key findings of this study was the relatively low rates of angiotensin-converting enzyme inhibitor (ACEI) angiotensin receptor blocker (ARB) and beta-blocker (BB) use in heart failure (HF) patients discharged from the hospital within three months, at 44.3% and 20.9%, respectively, from 1999 to 2000. Furthermore, o...

BACKGROUND Progressive enlargement of the aortic root, leading to dissection, is the main cause of premature death in patients with Marfan's syndrome. Recent data from mouse models of Marfan's syndrome suggest that aortic-root enlargement is caused by excessive signaling by transforming growth factor beta (TGF-beta) that can be mitigated by treatment with TGF-beta antagonists, including angiote...

Final offer arbitration (FOA) and conventional arbitration (ARE) are compared as mechanisms for settling labor disputes. It is recognized that the parties can manipulate their final offers under FOA in order to achieve a more desirable outcome, and the equilibrium pair of final offers is derived as a function of the uncertainty about the arbitrator's award and the relative risk preferences of t...

The role of renin-angiotensin system inhibitors (ACE-inhibitors) or angiotensin receptor blockers (ARB) in the renal transplant recipients (RTRs) is incompletely defined and according to the current guidelines they should be initiated after six months post-transplantation. The aim of the present paper is to evaluate the efficiency and safety of early (within six months post-transplantation) ver...

In this study, a kind of Al-TiB₂/TiC in situ composite was successfully prepared using the melt reaction method and the accumulative roll-bonding (ARB) technique. The microstructure evolution of the composites with different deformation treatments was characterized using field emission scanning electron microscopy (FESEM) and a transmission electron microscope (TEM). The mechanical properties o...