The amygdala plays a role in learning and memory processes that involve an emotional component. However, neural structures that regulate these amygdala-dependent processes are unknown. Previous studies indicate that regulation of affect may be imposed by the prefrontal cortex (PFC) and its efferents to the amygdala. The presentation of conditioned affective stimuli enhances activity of neurons ...

TNFR-associated factor (TRAF)6 is an essential ubiquitin E3 ligase in immune responses, but its function in adaptive immunity is not well understood. In this study, we show that TRAF6 is recruited to the peripheral ring of the T cell immunological synapse in Jurkat T cells or human primary CD4(+) T cells conjugated with staphylococcal enterotoxin E-pulsed B cells. This recruitment depends on TR...

Despite the growing number of gamma-ray sources detected by Fermi-LAT, about one third in each survey remains uncertain type. We present a new deep neural network approach for classification unidentified or unassociated last release Fermi-LAT catalogue (4FGL-DR2) obtained with 10 years data. In contrast to previous work, our method directly uses measurements photon energy spectrum and time seri...

The integral membrane adapter protein linker for activation of T cells (LAT) performs a critical function in T cell antigen receptor (TCR) signal transduction by coupling the TCR to downstream signaling pathways. After TCR engagement, LAT is tyrosine phosphorylated by ZAP-70 creating docking sites for multiple src homology 2-containing effector proteins. In the Jurkat T cell line, the distal fo...

Automatic open-domain Question Answering has been a long standing research challenge in the AI community. IBM Research undertook this challenge with the design of the DeepQA architecture and the implementation of Watson. This paper addresses a specific subtask of Deep QA, consisting of predicting the Lexical Answer Type (LAT) of a question. Our approach is completely unsupervised and is based o...

Recent studies have suggested that the latency-associated transcript (LAT) region of herpes simplex virus type 1 (HSV-1) is effective at blocking virus-induced apoptosis both in vitro and in the trigeminal ganglia of acutely infected rabbits (Inman et al., J. Virol. 75:3636-3646, 2001; Perng et al., Science 287:1500-1503, 2000). By transfecting cells with a construct expressing the Pst-Mlu segm...

A linear transformation on a finite-dimensional complex linear space has the property that all of its invariant subspaces are hyperinvariant if and only if its lattice of invariant subspaces is distributive [1]. It is shown that an operator on a complex Hilbert space has this property if its lattice of invariant subspaces satisfies a certain distributivity condition. 1. Preliminaries. Throughou...

1114 INSIGHTS | The Journal of Experimental Medicine TCR signaling, necessary for normal T cell development and T cell function, proceeds through the induction of protein phosphorylation of downstream molecules, including the membrane-anchored adaptor LAT. LAT, a substrate of the ZAP70 tyrosine kinase, is phosphorylated on multiple tyrosines that serve as docking sites for the recruitment of se...