an alumina supported co/ni catalyst was prepared by sol-gel procedure to study the catalytic behavior during fischer-tropsch synthesis in a fixed-bed reactor. the effect of co conversion (10-50%) on hydrocarbon product distribution (ch4, c5+ and c2-c4 olefin selectivities) was studied. selectivity for ch4 decreased, while those of c5+ and olefin selectivities increased with increasing co conver...

Ganciclovir (GCV) is the first therapeutic choice for prevention and treatment of active cytomegalovirus (CMV) infection in solid organ transplant recipients in Bahia state, Brazil. Prolonged and repeated GCV therapy may result in drug-resistant virus, associated with progressive and disseminated disease. We present a case report of a young male kidney recipient, who was CMV-seronegative with a...

We have previously demonstrated (L. Z. Rubsam et al., Cancer Res., 59: 669-675, 1999) that low ganciclovir (GCV) triphosphate (TP) levels similar to cellular deoxynucleotide concentrations can induce multilog killing in cells stably expressing herpes simplex virus thymidine kinase (HSV-TK). In this study, we evaluated whether reducing the endogenous competitor of GCV-TP, dGTP, enhanced GCV-medi...

Transfer of the herpes simplex thymidine kinase (HSV-TK) gene into tumor cells confers sensitivity to the cells to the viral drug ganciclovir (GCV). Although the efficacy of the HSV-TK/GCV approach is well studied, the mechanisms for the resistance of HSV-TK-transduced tumor cells to GCV are poorly understood. Here, we examined the mechanisms for GCV resistance in HSV-TK-transduced gastrointest...

Mixed-effect models are widely used for the analysis of correlated data such as longitudinal data and repeated measures. In this article, we study an approach to the nonparametric estimation of mixed-effect models. We consider models with parametric random effects and flexible fixed effects, and employ the penalized least squares method to estimate the models. The issue to be addressed is the s...

Ganciclovir (GCV) is a nucleoside analogue with antiviral activity against herpes viral infections, and the most widely used antiviral to treat cytomegalovirus infections. However, the low bioavailability and short half-life of GCV necessitate the development of a carrier for sustained delivery. In this study, guanosine-based GCV was used as the initiator directly in ring-opening polymerization...

Local polynomial fitting for univariate data has been widely studied and discussed, but up until now the multivariate equivalent has often been deemed impractical, due to the so-called curse of dimensionality. Here, rather than discounting it completely, we use density as a threshold to determine where over a data range reliable multivariate smoothing is possible, whilst accepting that in large...

Smoothing splines via the penalized least squares method provide versatile and effective nonparametric models for regression with Gaussian responses. The computation of smoothing splines is generally of the order O.n3/, n being the sample size, which severely limits its practical applicability. We study more scalable computation of smoothing spline regression via certain low dimensional approxi...

A simultaneous flexible variable selection procedure is proposed by applying a basis pursuit method to the likelihood function. The basis functions are chosen to be compatible with variable selection in the context of smoothing spline ANOVA models. Since it is a generalized LASSO-type method, it enjoys the favorable property of shrinking coefficients and gives interpretable results. We derive a...