The miR156-targeted squamosa promoter binding protein like (SPL) transcription factors function as an endogenous age cue in regulating plant phase transition and phase-dependent morphogenesis, but the control of SPL output remains poorly understood. In Arabidopsis thaliana the spatial pattern of trichome is a hallmark of phase transition and governed by SPLs. Here, by dissecting the regulatory ...

The superior parietal lobule (SPL) plays a pivotal role in many cognitive, perceptive, and motor-related processes. This implies that a mosaic of distinct functional and structural subregions may exist in this area. Recent studies have demonstrated that the ongoing spontaneous fluctuations in the brain at rest are highly structured and, like coactivation patterns, reflect the integration of cor...

Lateral inhibition is critical for cell fate determination and involves the functions of Notch (N) and its effectors, the Enhancer of Split Complex, E(spl)C repressors. Although E(spl) proteins mediate the repressive effects of N in diverse contexts, the role of phosphorylation was unclear. The studies we describe implicate a common role for the highly conserved Ser/Thr protein kinase CK2 durin...

Language: Analyzing Big Data in motion M. Hirzel H. Andrade B. Gedik G. Jacques-Silva R. Khandekar V. Kumar M. Mendell H. Nasgaard S. Schneider R. Soulé K.-L. Wu The IBM Streams Processing Language (SPL) is the programming language for IBM InfoSphereA Streams, a platform for analyzing Big Data in motion. By BBig Data in motion,[ we mean continuous data streams at high data-transfer rates. InfoS...

Simple partial logic (=SPL) is, broadly speaking, an extensional logic which allows for the truth-value gap. First I give a system of propositional SPL by partializing classical logic, as well as extending it with several non-classical truth-functional operators. Second I show a way based on SPL to construct a system of tensed ontology, by representing tensed statements as two kinds of necessar...

Cathepsin D is an estrogen (17P-estradio1, E,)-inducible lysosomal protease. A putative estrogen receptor (ER)-Spl-like sequence (GGGCGG(n),&CGGG) has been identified in the,non-coding strand of the cathepsin D promoter (-199 to -165), and electromobility shift assays of nuclear extracts from MCF-7 and HeLa cells confirm that both the ER and Spl protein bind to ”P-labeled EWSpl oligo. For examp...

BACKGROUND The recording of otoacoustic emissions (OAE) enabled us to prove that the cochlea is able not only to receive sounds but also to produce acoustic energy. Through the use of distortion-product otoacoustic emission measurements, the growth of the response was seen according to the intensity of the sound stimulus presented (growth curve). OBJECTIVE to determine the thresholds for the ...

Developers evolve software product lines (SPLs) manually or using typical program refactoring tools. However, when evolving an SPL to introduce new features or to improve its design, it is important to make sure that the behavior of existing products is not affected. Typical program refactorings cannot guarantee that because the SPL context goes beyond code and other kinds of core assets, and i...

Recent studies have described a phenomenon wherein the onset of a peripheral visual stimulus elicits short-latency (<100 ms) stimulus-locked recruitment (SLR) of neck muscles in nonhuman primates (NHPs), well before any saccadic gaze shift. The SLR is thought to arise from visual responses within the intermediate layers of the superior colliculus (SCi), hence neck muscle recordings may reflect ...

Spore photoproduct lyase (SPL) repairs a special thymine dimer, 5-thyminyl-5,6-dihydrothymine, which is commonly called spore photoproduct, or SP, in germinating endospores. SP is the exclusive DNA photo-damaging product found in endospores; its generation and swift repair by SPL are responsible for the spores' extremely high UV resistance. Early in vivo studies suggested that SPL utilizes a di...