Percutaneous Coronary Interventions (PCI) has become standard-of-care management of obstructive Coronary Artery Disease (CAD), Particularly in Acute Coronary Syndromes (ACS). Only balloon dilation i.e., plain old balloon angioplasty (POBA) despite reducing coronary stenosis and improving symptoms, had unacceptable restenosis rates and at times catastrophic abrupt vessel closure. A bare-metal St...

It is ironic that in 1964, Dotters’ initial application of percutaneous transluminal angioplasty (PTA) targeted femoral-popliteal stenoses. Now, nearly 4 decades later, although angioplasty has gained wide acceptance as a firstline treatment for diseased coronary, iliac, and renal arteries, its role in femoral-popliteal vessels remains controversial and poorly defined. The initial PTA procedure...

Objectives. We hypothesized that atherectomy would be superior to balloon angioplasty for ostial and nonostial left anterior descending coronary artery lesions. Background. Balloon angioplasty of ostial coronary artery lesions has been associated with a lower procedural success rate and a higher rate of complications and of restenosis than angioplasty of nonostial stenoses. Directional coronary...

Intracoronary stents have markedly improved the outcomes of catheter-based coronary interventions. Intracoronary stent implantation rates of over 90% during coronary angioplasty are common. Stent implantations are associated with a small but statistically significant number of adverse outcomes including restenosis, thrombosis, strut malapposition, incomplete strut endothelialization, and variou...

Kay IP, Ligthart JM, Thayssen P, van Den Brand MJ, de Feyter PJ, Serruys PW. Three dimensional intravascular ultrasonic assessment of the local mechanism of restenosis after balloon angioplasty. Heart 2001;85:73–79. 5. Costa MA, Simon DI. Molecular basis of restenosis and drug-eluting stents. Circulation 2005;111:2257–2273. 6. van der Giessen WJ, Lincoff AM, Schwartz RS, van Beusekom HM, Serruy...

Cardiovascular events are the most common cause of morbidity and mortality worldwide. Coronary artery diseases, including myocardial infarctions, prevalent among all populations. There multiple management strategies for coronary but stent implantation is effective interventions. Nevertheless, some patients develop restenosis intervened vessel, number constitutes about 10%-20% patients. In-stent...

OBJECTIVES The aim of this trial was to compare cutting balloon angioplasty (CBA) with conventional balloon angioplasty (i.e., percutaneous transluminal coronary angioplasty [PTCA]) for the treatment of patients with coronary in-stent restenosis (ISR). BACKGROUND Retrospective studies suggest CBA might be superior to conventional PTCA in the treatment of ISR. METHODS The Restenosis Cutting ...

Glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors were developed in the early 1990’s with the purpose of providing maximum platelet aggregation blockade. At first they were used adjunctly with balloon coronary angioplasty to reduce acute occlusion of the vessel treated and its complications such as periprocedural acute myocardial infarction (MI). The dissection of the vessel after balloon dilation...

AIMS Patients with diabetes mellitus have more extensive coronary artery disease, more disease progression, and restenosis. The use of drug-eluting stents (DES) in these patients is widespread, despite uncertain long-term safety and efficacy. METHODS AND RESULTS All consecutive patients with diabetes mellitus in Sweden who underwent percutaneous coronary intervention were entered into the Swe...

BACKGROUND It is known that there is an association between elevated total plasma homocysteine level and restenosis after percutaneous coronary angioplasty. OBJECTIVE To evaluate the effect of lowering plasma homocysteine levels on the rate of restenosis after stent-percutaneous coronary angioplasty. METHODS Folic acid (1 mg) or placebo was administered to 200 patients (mean +/- SD age of 5...