OBJECTIVE To demonstrate the feasibility of scheduling an IVF cycle, without disadvantages, in the new patient friendly stimulation protocol using the long acting Corifollitropin Alfa, in combination with GnRH-antagonist protection and GnRH-agonist triggering. STUDY DESIGN Two groups of ten patients were admitted in the study. Both received the same stimulation protocol with Corifollitropin A...

BACKGROUND Gonadotropin-releasing hormone (GnRH) plays essential roles in embryo implantation, invasion of trophoblastic tissue, and steroid synthesis in the placenta. OBJECTIVE The aim of this study was to evaluate the effect of GnRH antagonist administration on pregnancy outcomes in early implantation period. MATERIALS AND METHODS In this retrospective study, 94 infertile women undergoing...

Introduction A drawback of gonadotropin-releasing hormone (GnRH) antagonist protocols in in vitro fertilization (IVF) is that they have limited flexibility in cycle programming. This proof of concept study explored the efficacy of a single-dose, long-acting GnRH antagonist IVF protocol. Trial registration number is NCT03240159, retrospectively registered on March 08, 2017. Materials and metho...

STUDY QUESTION Are there factors predicting the number of total and mature oocytes retrieved after controlled ovarian hyperstimulation (COH) utilizing a gonadotropin-releasing hormone (GnRH) antagonist protocol and a GnRH agonist (GnRHa) to induce oocyte maturation? SUMMARY ANSWER Peak estradiol (E₂) level, post-trigger LH and progesterone and the magnitude of LH rise are independent predicto...

Microglia are the specialized population of macrophage-like cells brain. They play essential roles in both physiological and pathological brain functions. Most our current understanding microglia is based on experiments performed mouse. Human differ from mouse microglia, thus response characteristics may not always represent that human microglia. Further, due to ethical technical difficulties, ...

Sigma-1 receptor (S1R) is an intracellular, multi-functional, ligand operated protein that also acts as a chaperone. It considered pluripotent drug target in several pathologies. The publication of agonist and antagonist bound structures has paved the way for receptor-based silico design. However, recent studies on this subject payed no attention to structural differences binding. In work, we h...

OBJECTIVE To investigate outcomes of stimulated IVF cycles in which GnRH antagonist was omitted on the ovulation triggering day. METHODS A total of 86 women who underwent controlled ovarian hyperstimulation with recombinant FSH and GnRH antagonist flexible multiple-dose protocols were recruited and prospectively randomized into the conventional group (group A) or cessation group (group B). Th...

Introduction Aripiprazole is the third generation Antipsychotic, and Dopamine serotonin system stabiliser.It partial agonist at D2 5 HT1 A antagonist HT2.Most commonly seen adverse effects are Akathesia, fatugue,insomnia headache major advanatage less propensity for extrapyramidal side lmetabolic eefects. Objectives To report a case of Schizophrenia treated with 15mg/day developiing occular gyr...

OBJECTIVE To evaluate whether letrozole incorporated in a gonadotrophin-releasing hormone (GnRH) antagonist multiple dose protocol (MDP) improved controlled ovarian stimulation (COS) and in vitro fertilization (IVF) results in poor responders who underwent IVF treatment. METHODS In this retrospective cohort study, a total of 103 consecutive IVF cycles that were performed during either the let...