BACKGROUND The presence of rheumatoid factor (RF), anti-carbamylated protein antibodies (anti-CarP) and antibodies against citrullinated protein and peptides (ACPA) precedes the onset of symptoms of rheumatoid arthritis (RA) by several years. Relationships between the development of these antibodies are not obvious. METHODS Three isotypes [immunoglobulin A (IgA), IgG and IgM) of RF were analy...

The prognostic value of two antibodies targeting citrullinated antigens, anti-Sa and anti-cyclic citrullinated peptide (CCP), present at inclusion, was evaluated prospectively in a cohort of 165 consecutive patients with recent-onset or early polyarthritis (EPA) followed for up to 30 months. Patients were treated according to current Good Clinical Practice standards. Predefined outcomes were se...

OBJECTIVES To investigate the presence and characteristics of citrullinated vimentin in protein extracts of inflamed synovial tissue. METHODS Cytosolic protein extracts obtained from RA (n = 14) and SpA patients (n = 14) were analysed by gel electrophoresis and western blotting. Citrullinated vimentin isoforms were visualized by a combination of anti-modified citrulline (AMC) staining and ant...

AIM The purpose of present study was to access the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in children with Juvenile Idiopathic Arthritis (JIA), and to investigate the clinical significance and diagnostic value of the anti-CCP antibodies in correlation with age, sex & activity. METHODS This case-control study was performed on 50 patients with JIA in addition to 4...

Rheumatoid Arthritis (RA) has been associated with several autoantibodies, including antiperinuclear factor, anti-keratin antibodies, anti-filaggrin antibodies, and anti-Cyclic Citrullinated Peptide (anti-CCP) antibodies. Most studies found that anti-CCP antibodies are only detected in Juvenile Rheumatoid Arthritis (JRA) patients with positive Rheumatoid Factor (RF). In our center we experiment...

Background: Rheumatoid arthritis (RA) is associated with HLA-DRB1 genes encoding the shared epitope (SE), a 5 amino acid motive. RA usually preceded by emergence of anti-citrullinated protein antibodies (ACPAs) detected anti-CCP2 tests. Citrullin neutral resulting from post translational modification arginin Peptidyl Arginyl Deiminases (PADs). ACPAs recognize epitopes citrullinated human fibrin...

Background Rheumatoid arthritis (RA) is a chronic, debilitating disease associated with reduced quality of life. It characterized by the positivity various antibodies, most specific being autoantibodies against citrullinated antigens (ACPA). Those antibodies are severe erosive phenotype and higher mortality rate comparisons to seronegative RA. Moreover, ACPA status known be favorable response b...